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11-14-23 Drs. Tet Nakao and Pradeep Natarajan published a letter in the New England Journal of Medicine Familial Clonal Hematopoiesis in a Long Telomere Syndrome
11-14-23 Drs. Akl Fahed and Pradeep Natarajan recently published in Atherosclerosis Clinical applications of polygenic risk score for coronary artery disease through the life course.
10-31-23 Flagship MGB Biobank paper by Dr. Satoshi Koyama is up as a preprint! Decoding Genetics, Ancestry, and Geospatial Context for Precision Health.
10-20-23 Congratulation Dr. Zhi Yu for being named a Stat Wunderkid
10-13-23 A recent collaboration with Dr. Lauren Reescamp and the Natarajan Lab led to this publication: Concordance of a High Lipoprotein(a) Concentration Among Relatives.
10-11-23 A big congratulations to Yuxuan Wang et al for the recent medRxiv preprint. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study.
9-29-23 Congratulations Dr. Sarah Urbut and the rest of the lab! Published in iScience Bayesian multivariate genetic analysis improves translational insights.
9-15-23 Congratulations to Dr. Zhi Yu on her K99 NOA!
9-15-23 Jiwoo Lee, one of our medical students, just published in Nature Communications. Quantifying the causal impact of biological risk factors on healthcare costs.
8-28-23 Congratulations, Dr. Jemma So Mi Cho and Nina Kathiresan! Published in JAMA Cardiology. Representation of Race and Ethnicity in the Contemporary US Health Cohort All of US Research Program.
8-2-23 Dr. Zhi Yu is on fire! She published this work Genetic modification of inflammation and clonal hematopoiesis- associated cardiovascular risk in the Journal of Clinical Investigation. Her preprint Human Plasma Proteomic Profile of Clonal Hematopoiesis is also up.
7-27-23 Congrats Art Schuermans et al. for your publication in Circulation Research. Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women.
7-7-23 Amazing work Aniruddh Patel! Published in Nature Medicine A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.
6-27-23 The Natarajan folks have been busy. Art Schuermans, Sara Haidermota, and Drs Tet Nakao, Yunfeng Ruan, Satoshi Koyama, Zhi Yu, Mesbah Uddin, Whitney Hornsby, Pradeep Natarajan, and Mike Honigberg all contributed to this Nature Genetics paper Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood.
6-27-23 Jemma So Mi Cho along with a few other lab folks recently published Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study.
6-16-23 Drs. Derek Klarin, Kaavya Paruchuri, Krishna Aragam, Ida Surakka, and Pradeep Natarajan all contributed to this Nature Genetics paper Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.
5-17-23 A Nature publication published in April. Clonal haematopoiesis and risk of chronic liver disease.
4-26-23 A truly joint lab effort Genetic and Clinical Factors Underlying a Self-Reported Family History of Heart Disease.
3-17-23 Our latest publication Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.
12-9-22 Just published Clonal Hematopoiesis and Risk of Incident Lung Cancer.
11-11-22 A couple more publications to end this week. 2022 Jeffrey M. Hoeg Award Lecture: Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease and Venous Thromboembolism Polygenic Risk Score Associates With Pulmonary Hypertension in the UK Biobank.
11-08-22 This week, Drs. Tetsushi Nakao and Pradeep Natarajan published Clonal hematopoiesis, multi-comics and coronary artery disease in Nature Cardiovascular Research.
11-08-22 Circulation: Genomic and Precision Medicine just published Association of a Multi-Ancestry Genome-Wide Blood Pressure Polygenic Risk Score with Adverse Cardiovascular Events
11-04-22 Our latest publication in Blood Clonal hematopoiesis of indeterminate potential and risk of death from COVID-19
10-19-22 A new publication for the Natarajan Lab, Clonal Hematopoiesis of Indeterminate Potential and Kidney Function Decline in the General Population.
10-13-22 Just published in Nature Communications Whole genome sequence analysis of blood lipid levels in >66,000 individuals.
09-30-22 Ending off September with two publications Measured Blood Pressure, Genetically Predicted Blood Pressure, and Cardiovascular Disease Risk in the UK Biobank and Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes.
09-20-22 Considering a career as a physician-scientist? Here’s a timely publication: Launching a career as a physician-scientist.
09-20-22 Just published in Science Translational Medicine Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.
09-13-22 Congratulations Mesbah Uddin and the Natarajan Lab for their recently published paper, Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease
08-30-22 The latest paper to close out August, Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.
08-23-22 The Natarajan Lab recently published Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods and Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.
08-18-22 For the long days of summer, here is some light reading. Clinical Implementation of Combined Monogenic and Polygenic Risk Disclosure for Coronary Artery Disease.
08-10-22 Newsweek just announced that Massachusetts General Hospital has been chosen as the #1 hospital in the world for cardiology. Honored to work alongside this amazing group of colleagues!
08-08-22 For the hot days of August! A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
08-02-22 More summer reading! Large-scale genome-wide association study of coronary artery disease in genetically diverse populations and Germline genomic and phenomic landscape of clonal hematopoiesis in 323,112 individuals.
07-21-22 A summer publication to add to your reading list! Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality
07-01-22 To start out the second half of the year, the lab published this article: A MUC5B Gene Polymorphism, rs35705950-T Confers Protective Effects Against COVID-19 Hospitalization but not Severe Disease or Mortality
06-29-22 Two new articles published this month. TET2-mutant clonal hematopoiesis and risk of gout and the Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait.
06-16-22 Nature Genetics published the Natarajan Lab’s most recent work, Genetic analysis of right heart structure and function in 40,000 people.
06-13-22 Welcome to Shriie Ganesh. She joined our incredibly talented group of clinical research coordinators.
06-03-22 Two publications to note from the past couple of weeks. Genetic Architecture and Clinical Outcomes of the Fredrickson-Levy-Lees Dyslipoproteinemias and Sex Differences in Temporal Trends of Cardiovascular Health in Young US Adults.
05-24-22 On May 14th the American Heart Association Vascular Discovery Scientific Sessions held in Seattle awarded Dr. Pradeep Natarajan with the Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award. Congratulations Pradeep!
05-12-22 A mid-May publication. Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality.
05-05-22 Read a few of the papers published during April and May. “Genetics of smoking and risk of clonal hematopoiesis“, “Lipoprotein(a), menopausal hormone therapy, and risk of coronary heart disease in postmenopausal women“, “Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential“, and “Genetic association of body mass index with pathologic left ventricular remodeling“.
4-25-22 Our new Associate Director, Whitney Hornsby, joined the Natarajan Lab today!
03-14-22 Another week of publications for the Natarajan Lab. “Genetic and phenotypic profiling of supranormal ejection fraction reveals decreased survival and underdiagnosed heart failure” and “Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society For Preventive Cardiology Clinical Practice Statement“.
03-08-22 Congratulations Maryam Zekavat for defending her PhD and for the publication of her most recent work. “Fibrillar Collagen Variants in Spontaneous Coronary Artery Dissection“.
03-07-22 Yet more papers published “Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society for Preventive Cardiology Clinical Practice Statement.” and “Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study“.
2-28-22 The next paper out from the Natarajan Lab is “Diastolic Blood Pressure Alleles Improve Congenital Heart Defect Repair Outcomes.”
2-18-22 A slew of papers have been published over the last month in the Natarajan Lab. Here are a few of them. Michael Honigberg presented his latest research in “Microvascular Outcomes in Women With a History of Hypertension in Pregnancy“. Mark Trinder published his work titled “Repeat Measures of Lipoprotein(a) Molar Concentration and Cardiovascular Risk“. Base on her most recent studies, Leland Hull published her piece “Self-rated family health history knowledge among All of Us program participants“. Watch here for more publications!
11-8-21 Congratulations to the Natarajan Lab including Maryam Zekevat, Vineet Raghu, Mark Trinder, Satoshi Koyama, Mike Honigberg, Zhi Yu, Sarah Urbut, Sara Haidermota, and Pradeep Natarajan for publishing Deep Learning of the Retina Enables Phenome- and Genome-wide Analyses of the Microvasculature .
10-18-21 Despite being in her first year as a Cardiology Fellow, Dr. Sarah Urbut came in 2nd place in the Fellows Basic Science Category at the Northwestern Cardiovascular Young Investigators’ Forum. Congratulations Dr. Urbut!
9-28-21 Newsweek published their list of the world’s Best Specialized Hospitals 2022 – Cardiology. At the top, you will find the Massachusetts General Hospital Corrigan Minehan Heart Center! Congratulations to all who make this a world-class center.
Pradeep Natarajan Follow
Dir of Prev Cardiology @MassGeneralNews | Assoc Prof @harvardmed | Assoc Mem @broadinstitute | Assoc Ed @JAMACardio @ScienceAdvances
10 years ago, with a small group of MGH cardiologists including @eisselbacher and then @JagSinghMD , we started an electronic consult service. It quickly became 8% of all referrals and the model has led to e-consults throughout essentially all clinical services @MassGenBrigham
'One-liners' of all the late-breaking trials 🔥 presented at #AHA23 👇 @AHAScience
I am super-excited to see this collaborative manuscript now out: Genetic determinants of blood gene expression and splicing and their contribution to molecular phenotypes and health outcomes!
Data portal: https://www.intervalrna.org.uk/
On #GivingTuesday, consider supporting our ambitious efforts to comprehensively understand the drivers of cardiometabolic disease across South Asian communities living in the US.
https://because.massgeneral.org/campaign/our-health-a-transformative-initiative-for-south-asian-cardiac-health-research-spearheaded-by-mgh/c348220 @broadinstitute @MGHHeartHealth @MGH_RI
The first genome sequence of a human cancer was reported 15 years ago. As @shengfcai & @rosslevinemd discuss, this ushered in a new era of diagnostic, prognostic and therapeutic advances.