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[Updated 2/25/2021]

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 Academic Journals

Am J Cardiology (2), Anat Sci Educ (1), Arterioscler Thromb Vasc Biol (3), Biochem Biophys Res Commun (1), Blood (1), BMC Endocr Disord (1), Cardiovasc Digital Health J (1), Cardiovasc Res (2), Cell Stem Cell (1), Circ Genom Precis Med (7), Circ Res (2), Circulation (11), Clin Cardiol (1), Coron Artery Dis (1), Curr Opin Genet Dev (1), Curr Treat Options Cardiovasc Med (1), Diabetes (2), EClinicalMedicine (1), Eur Heart J: Case Rep (1), Eur J Prev Cardiol (2), Genet Med (1), Hypertension (1), J Am Coll Cardiol (10), J Am Heart Assoc (1), J Hosp Med (1), JACC Basic Transi Sci (1), JACC Cardiovasc Imaging (1), JAMA (6), JAMA Cardiol (1), J Biol Chem (1), Lancet Digit Health (1), Med (1), N Engl J Med (3), Nat Commun (6), Nat Genet (6), Nat Med (6), Nat Neurosci (1), Nature (5), PLoS One (1), Proc Natl Acad Sci U.S.A. (1), Sci Rep (1), Sci Transl Med (1), Science (1)

Highlighted papers

 Unpublished Preprints

114.  Nakao T, Bick AG, Taub MA, Zekavat SM, Uddin M, Niroula A, Carty CL, Lane J, Honigberg MC, Weinstock JS, Pampana A, Gibson CJ, Griffin GK, Clarke SL, Bhattacharya R, Assimes TL, Emery LS, Stilp AM, Wong QBroome J, Laurie CA, Khan AT, Smith AV, Blackwell TW, Yoneda ZT, Peralta JM, Bowden DW, Irvin MR, Boorgula M, Zhao W, Yanek LR, Wiggins KL, Hixson JE, Gu CC, Peloso GM, Roden DM, Reupena MS, Hwu CM, DeMeo DL, North KE, Kelly S, Musani SK, Bis JC, Lloyd-Jones DM, Johnsen JM, Preuss M, Tracy RP, Peyser PA, Qiao D, Desai P, Curran JE, Freedman BI, Tiwari HK, Chavan S, Smith JA, Smith NL, Kelly TN, Hildalgo B, Cupples LA, Weeks DE, Hawley NL, Minster RL, The Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, Deka R, Naseri TT, de las Fuentes L, Raffield LM, Tracy RP, Morrison AC, Vries PS, Ballantyne CM, Kenny EE, Rich SS, Whitsel EA, Cho MH, Shoemaker MB, Pace BS, Blangero J, Palmer ND, Mitchell BD, Shuldiner AR, Barnes KC, Redline S, Kardia SLR, Abecasis GR, Becker LC, Heckbert SR, He J, Post W, Arnett DK, Vasan RS, Darbar D, Weiss ST, McGarvey ST, de Andrade M, Chen YDI, Kaplan RC, Meyers DA, Custer BS, Correa A, Psaty BM, Fornage M, Manson JE, Boerwinkle E, Konkle BA, Loos RJF, Rotter JI, Silverman EK, Kooperberg C, Jaiswal S, Libby P, Ellinor PT, Pankratz N, Ebert BL, Reiner AP, Mathias RA, Do R, NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Natarajan P. Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential.

113. Hindy G, Dornbos P, Chaffin MD, Liu DJ, Wang M, Aguilar-Salinas CA, Antonacci-Fulton L, Ardissino D, Arnett DK, Aslibekyan S, Atzmon G, Ballantyne CM, Barajas-Olmos F, Barzilai N, Becker LC, Bielak LF, Bis JC, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Bown MJ, Brody JA, Broome JG, Burtt NP, Cade BE, Centeno-Cruz F, Chan E, Chang Chen YCI, Cheng CCY, Choi WJ, Chowdhury R, Contreras-Cubas C, Córdova EJ, Correa A, Cupples LA, Curran JE, Danesh J, de Vries PS, DeFronzo RA, Doddapaneni H, Duggirala R, Dutcher SK, Ellinor PT, Emery LS, Florez JC, Fornage M, Freedman BI, Fuster V, Garay-Sevilla ME, García-Ortiz H, Germer S, Gibbs RA, Gieger C, Glaser B, Gonzalez C, Gonzalez-Villalpando ME, Graff M, Graham SE, Grarup N, Groop LC, Guo X, Gupta N, Han S, Hanis CL, Hansen T, He J, Heard-Costa NL, Hung YJ, Hwang MY, Irvin MR, Islas-Andrade S, Jarvik GP, Kang HM, Kardia SLR, Kelly T, Kenny EE, Khan AT, Kim BJ, Kim RW, Kim YJ, Koistinen HA, Kooperberg C, Kuusisto J, Kwak SH, Laakso M, Lange LA, Lee J, Lee J, Lee S, Lehman DM, Lemaitre RN, Linneberg A, Liu J, Loos RJF, Lubitz SA, VLyssenko V, Ma RCW, Martin LW, Martínez-Hernández A, Mathias RA, McGarvey ST, McPherson R, Meigs JB, Meitinger T, Melander O, Mendoza-Caamal E, Metcalf GA, Mi X, Mohlke KL, Montasser ME, Moon JY, Moreno-Macías H, Morrison AC, Muzny DM, Nelson SC, Nilsson PM, O’Connell JR, Orho-Melander M, Orozco L, Palmer CNA, Palmer ND, Park CJ, Park KS, Pedersen O, Peralta JM, Peyser PA, Post WS, Preuss M, Psaty BM, Qi Q, Rao DC, Redline S, Reiner AP, Revilla-Monsalve C, Rich SS, Samani N, Schunkert H, Schurmann C, Seo D, Seo JS, Sim X, Sladek R, Small KS, So WY, Stilp AM, Sunitha SM, Tai ES, Tam CHT, Taylor KD, Teo YY, Thameem F, Tomlinson B, Tsai MY, Tuomi T, Tuomilehto J, Tusié-Luna T, van Dam RM, Vasan RS, Viaud Martinez KA, Wang FF, Wang X, Watkins H, Weeks DE, Wilson JG, Witte DR, Wong TY, Yanek LR, AMP-T2D-GENES, Myocardial Infarction Genetics Consortium, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, NHLBI TOPMed Lipids Working Group, Kathiresan S, Rotter JI, Boehnke M, McCarthy MI, Willer CJ, Natarajan P, Flannick JA, Khera AV, Peloso GM. Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes. bioRxiv. 2020 Dec 23:2020.12.22.423783; doi: https://doi.org/10.1101/2020.12.22.423783.

112. Zekavat SM*, Lin SH*, Bick AG, Liu A, Paruchuri K, Uddin MM, Ye Y, Yu Z, Liu X, Kamatani Y, Pirruccello JP, Pampana A, Loh PR, Kohli P, McCarroll SA, Neale B, Engels EA, Brown DW, Smoller JW, Green R, Karlson EW, Lebo M, Ellinor PT, Weiss ST, Daly MJ, Terao C, Zhao H, Ebert BL, Ganna A, Machiela MJ*, Genovese G*, Natarajan P*. Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer. medRxiv [Preprint]. 2020 Nov 16:2020.11.12.20230821. doi: 10.1101/2020.11.12.20230821. PMID: 33236019; PMCID: PMC7685330.

111. Bolton KL, Koh Y, Foote MB, Im H, Jee J, Sun CH, Safonov A, Ptashkin R, Moon JH, Lee JY, Jung J, Kang CK, Song KH, Choe PG, Park WB, Kim HB, Oh MD, Song H, Kim S, Patel M, Derkach A, Gedvilaite E, Tkachuk KA, Braunstein LZ, Gao T, Papaemmanuil E, Babady NE, Pessin MS, Kamboj M, Diaz LA, Ladanyi M, Rauh MJ, Natarajan P, Machiela MJ, Awadalla P, Joseph V, Offit K, Norton L, Berger MF, Levine RL, Kim ES, Kim NJ, Zehir A. Clonal hematopoiesis is associated with risk of severe Covid-19. medRxiv [Preprint]. 2020 Nov 27:2020.11.25.20233163. doi: 10.1101/2020.11.25.20233163. PMID: 33269365; PMCID: PMC7709186.

110. Paruchuri K, Finneran P, Marston NA, Healy EW, Andreo Jr J, Lynch R, Blood AJ, Jones-O’Connor M, Lander B, Kelly N, Vivaldi MT, Traynor K, Wiviott S, Natarajan P. Outcomes of a Smartphone-based Application with Live Health-Coaching Post-Percutaneous Coronary Intervention. medRxiv. 2020 Nov 12:2020.11.08.20217653; doi: https://doi.org/10.1101/2020.11.08.20217653.

109. Bick AG*, Popadin K*, Thorball CW, Uddin MM, Zanni M, Yu B, Cavassini M, Rauch A, Tarr P, Schmid P, Bernasconi E, Gunthard H, Libby P, Boerwinkle E, McLaren P, Ballantyne CM, Grinspoon SK, Natarajan P*, Fellay J*. Increased CHIP Prevalence Amongst People Living with HIV. medRxiv [Preprint]. 2020 Nov 7:2020.11.06.20225607. doi: 10.1101/2020.11.06.20225607. PMID: 33173934; PMCID: PMC7654930.

108. Smith GA, Pampana A, Natarajan P, Shokat KM, Chorba JS. Genome-Wide Screening Reveals CSDE1 as a Novel Regulator of the LDL Receptor. doi: https://doi.org/10.1101/2020.08.03.235028. 2020. bioRxiv.

107. Lee J, Kiiskinen T, Mars N, Jukarainen S, FinnGen Project, Ingelsson E, Neale B, Ripatti S, Natarajan P*, Ganna A*. Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome. medRxiv 2020 Sep 18: 2020.09.16.20195883; doi: https://doi.org/10.1101/2020.09.16.20195883

106. Brockman DG, Austin-Tse CA, Pelletier RC, Harley C, Patterson C, Head H, Leonard CE, O’Brien K, Mahanta LM, Lebo MS, Lu CY, Natarajan P, Khera AV, Aragam KG, Kathiresan S, Rehm HI, Udler M. Prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test. doi: https://doi.org/10.1101/2020.09.03.20181073. 2020. medRxiv.

105. Levin MG, Klarin D, Walker VM, Gill D, Lynch J, Lee KM, Assimes TL, Natarajan P, Hung A, Edwards TL, Rader DJ, Gaziano JM, Davies NM, Tsao PS, Chang KM, Voight BF, Damrauer SM, VA Million Veteran Program. Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study. doi: https://doi.org/10.1101/2020.08.23.20180240. 2020. medRxiv.

104. Stilp AM*, Emery LS*, Broome JG, Buth EJ, Khan AT, Laurie CA, Wang FF, Wong Q, Chen D, D’Augustine CM, Heard-Costa NL, Hohensee CR, Johnson WC, Juarez LD, Liu J, Mutalik KM, Raffield LM, Wiggins KL, de Vries PS, Kelly TN, Kooperberg C, Natarajan P, Peloso GM, Peyser PA, Reiner AP, Arnett DK, Aslibekyan S, Barnes KC, Bielak LF, Bis JC, Cade BE, Chen MH, Correa A, Cupples LA, de Andrade M, Ellinor PT, Fornage M, Franceschini N, Gan W, Ganesh SK, Graffelman J, Grove ML, Guo X, Hawley NL, Hsu WL, Jackson RD, Jaquish CE, Johnson AD, Kardia SLR, SKelly S, Lee J, Mathias RA, McGarvey ST, Mitchell BD, Montasser ME, Morrison AC, North KE, Nouraie SM, Oelsner EC, Pankratz N, Rich SS, Rotter JI, Smith JA, Taylor KD, Vasan RS, Weeks DE, Weiss ST, Wilson CG, Yanek LR, Psaty BM, Heckbert SR, Laurie CC. A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program. doi: https://doi.org/10.1101/2020.06.18.146423. 2020. bioRxiv.

103. Katz DH, Tahir UA, Ngo D, Benson MD, Bick AG, Pampana A, Gao Y, Keyes MJ, Correa A, Sinha S, Shen D, Yang Q, Robbins JM, Chen ZZ, Cruz DE, Peterson B, Natarajan P, Vasan RS, Smith G, Wang TJ, Gerszten RE. Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19. medRxiv [Preprint]. 2020 Jun 11:2020.06.09.20125690. doi: 10.1101/2020.06.09.20125690. PMID: 32577670; PMCID: PMC7302224.

102. Finneran PA, Sanborn T, Guo X, Traynor KC, Jaff MR, Natarajan P. Assessment and Utilization of Patient-Reported Outcomes Measures to Improve Cardiovascular Disease Prevention. doi: 10.1101/2019.12.11.19014399. 2019 medRxiv.

 Published

101. Finneran P, Pampana A, Khetarpal SA, Trinder M, Patel AP, Paruchuri K, Aragam K, Peloso GM, Natarajan P. Lipoprotein(a) and Coronary Artery Disease Risk Without a Family History of Heart Disease. J Am Heart Assoc. 2021 Feb 26:e017470. doi: 10.1161/JAHA.120.017470. Epub ahead of print. PMID: 33631942.

100.Trinder M, Zekavat SM, Uddin MM, Pampana A, Natarajan P. Apolipoprotein B is an insufficient explanation for the risk of coronary disease associated with lipoprotein(a). Cardiovasc Res. 2021 Feb 24:cvab060. doi: 10.1093/cvr/cvab060. Epub ahead of print. PMID: 33629108.

99. Haring B, Reiner AP, Liu J, Tobias DK, Whitsel E, Berger JS, Desai P, Wassertheil-Smoller S, LaMonte MJ, Hayden KM, Bick AG, Natarajan P, Weinstock JS, Nguyen PK, Stefanick M, Simon MS, Eaton CB, Kooperberg C, Manson JE. Healthy Lifestyle and Clonal Hematopoiesis of Indeterminate Potential: Results From the Women’s Health Initiative. J Am Heart Assoc. 2021 Feb 23:e018789. doi: 10.1161/JAHA.120.018789. Epub ahead of print. PMID: 33619969.

98.Honigberg MC, Zekavat SM, Niroula A, Griffin GK, Bick AG, Pirruccello JP, Nakao T, Whitsel EA, Farland LV, Laurie C, Kooperberg C, Manson JE, Gabriel S, Libby P, Reiner AP, Ebert BL; NHLBI Trans-Omics for Precision Medicine Program, Natarajan P. Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women. Circulation. 2021 Feb 2;143(5):410-423. doi: 10.1161/CIRCULATIONAHA.120.051775. Epub 2020 Nov 9. PMID: 33161765.

97. Taliun D*, Harris DN*, Kessler MD*, Carlson J*, Szpiech ZA*, Torres R*, Taliun SAG*, Corvelo A*, Gogarten SM, Kang HM, Pitsillides AN, LeFaive J, Lee SB, Tian X, Browning BL, Das S, Emde AK, Clarke WE, Loesch DP, Shetty AC, Blackwell TW, Smith AV, Wong Q, Liu X, Conomos MP, Bobo DM, Aguet F, Albert C, Alonso A, Ardlie KG, Arking DE, Aslibekyan S, Auer PL, Barnard J, Barr RG, Barwick L, Becker LC, Beer RL, Benjamin EJ, Bielak LF, Blangero J, Boehnke M, Bowden DW, Brody JA, Burchard EG, Cade BE, Casella JF, Chalazan B, Chasman DI, Chen YI, Cho MH, Choi SH, Chung MK, Clish CB, Correa A, Curran JE, Custer B, Darbar D, Daya M, de Andrade M, DeMeo DL, Dutcher SK, Ellinor PT, Emery LS, Eng C, Fatkin D, Fingerlin T, Forer L, Fornage M, Franceschini N, Fuchsberger C, Fullerton SM, Germer S, Gladwin MT, Gottlieb DJ, Guo X, Hall ME, He J, Heard-Costa NL, Heckbert SR, Irvin MR, Johnsen JM, Johnson AD, Kaplan R, Kardia SLR, Kelly T, Kelly S, Kenny EE, Kiel DP, Klemmer R, Konkle BA, Kooperberg C, Köttgen A, Lange LA, Lasky-Su J, Levy D, Lin X, Lin KH, Liu C, Loos RJF, Garman L, Gerszten R, Lubitz SA, Lunetta KL, Mak ACY, Manichaikul A, Manning AK, Mathias RA, McManus DD, McGarvey ST, Meigs JB, Meyers DA, Mikulla JL, Minear MA, Mitchell BD, Mohanty S, Montasser ME, Montgomery C, Morrison AC, Murabito JM, Natale A, Natarajan P, Nelson SC, North KE, O’Connell JR, Palmer ND, Pankratz N, Peloso GM, Peyser PA, Pleiness J, Post WS, Psaty BM, Rao DC, Redline S, Reiner AP, Roden D, Rotter JI, Ruczinski I, Sarnowski C, Schoenherr S, Schwartz DA, Seo JS, Seshadri S, Sheehan VA, Sheu WH, Shoemaker MB, Smith NL, Smith JA, Sotoodehnia N, Stilp AM, Tang W, Taylor KD, Telen M, Thornton TA, Tracy RP, Van Den Berg DJ, Vasan RS, Viaud-Martinez KA, Vrieze S, Weeks DE, Weir BS, Weiss ST, Weng LC, Willer CJ, Zhang Y, Zhao X, Arnett DK, Ashley-Koch AE, Barnes KC, Boerwinkle E, Gabriel S, Gibbs R, Rice KM, Rich SS, Silverman EK, Qasba P, Gan W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Papanicolaou GJ, Nickerson DA, Browning SR, Zody MC, Zöllner S, Wilson JG, Cupples LA, Laurie CC, Jaquish CE, Hernandez RD, O’Connor TD, Abecasis GR. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021 Feb;590(7845):290-299. doi: 10.1038/s41586-021-03205-y. Epub 2021 Feb 10. PMID: 33568819.

96. Ye Y, Chen X, Han J, Jiang W, Natarajan P, Zhao H. Interactions Between Enhanced Polygenic Risk Scores and Lifestyle for Cardiovascular Disease, Diabetes, and Lipid Levels. Circ Genom Precis Med. 2021 Feb;14(1):e003128. doi: 10.1161/CIRCGEN.120.003128. Epub 2021 Jan 12. PMID: 33433237; PMCID: PMC7887077.

95. Levin MG, Klarin D, Assimes TL, Freiberg MS, Ingelsson E, Lynch J, Natarajan P, O’Donnell C, Rader DJ, Tsao PS, Chang KM, Voight BF, Damrauer SM; VA Million Veteran Program. Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study. JAMA Netw Open. 2021 Jan 4;4(1):e2034461. doi: 10.1001/jamanetworkopen.2020.34461. PMID: 33464320; PMCID: PMC7816104.

94. Nielsen JB*, Rom O*, Surakka I*, Graham SE*, Zhou W*, Roychowdhury T, Fritsche LG, Gagliano Taliun SA, Sidore C, Liu Y, Gabrielsen ME, Skogholt AH, Wolford B, Overton W, Zhao Y, Chen J, Zhang H, Hornsby WE, Acheampong A, Grooms A, Schaefer A, Zajac GJM, Villacorta L, Zhang J, Brumpton B, Løset M, Rai V, Lundegaard PR, Olesen MS, Taylor KD, Palmer ND, Chen YD, Choi SH, Lubitz SA, Ellinor PT, Barnes KC, Daya M, Rafaels N, Weiss ST, Lasky-Su J, Tracy RP, Vasan RS, Cupples LA, Mathias RA, Yanek LR, Becker LC, Peyser PA, Bielak LF, Smith JA, Aslibekyan S, Hidalgo BA, Arnett DK, Irvin MR, Wilson JG, Musani SK, Correa A, Rich SS, Guo X, Rotter JI, Konkle BA, Johnsen JM, Ashley-Koch AE, Telen MJ, Sheehan VA, Blangero J, Curran JE, Peralta JM, Montgomery C, Sheu WH, Chung RH, Schwander K, Nouraie SM, Gordeuk VR, Zhang Y, Kooperberg C, Reiner AP, Jackson RD, Bleecker ER, Meyers DA, Li X, Das S, Yu K, LeFaive J, Smith A, Blackwell T, Taliun D, Zollner S, Forer L, Schoenherr S, Fuchsberger C, Pandit A, Zawistowski M, Kheterpal S, Brummett CM, Natarajan P, Schlessinger D, Lee S, Kang HM, Cucca F, Holmen OL, Åsvold BO, Boehnke M, Kathiresan S, Abecasis GR, Chen YE*, Willer CJ*, Hveem K*. Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease. Nat Commun. 2020 Dec 18;11(1):6417. doi: 10.1038/s41467-020-20086-3. PMID: 33339817; PMCID: PMC7749177.

93. Samuel RM*, Majd H*, Richter MN*, Ghazizadeh Z*, Zekavat SM*, Navickas A*, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. Cell Stem Cell. 2020 Dec 3;27(6):876-889.e12. doi: 10.1016/j.stem.2020.11.009. Epub 2020 Nov 17. PMID: 33232663; PMCID: PMC7670929.

92. Natarajan A, Pantelopoulos A, Emir-Farinas H, Natarajan P. Heart rate variability with photoplethysmography in 8 million individuals: a cross-sectional study. Lancet Digit Health. 2020 Dec;2(12):e650-e657. doi: 10.1016/S2589-7500(20)30246-6. Epub 2020 Nov 23. PMID: 33328029.

91. Zekavat SM, Honigberg M, Pirruccello JP, Kohli P, Karlson EW, Newton-Cheh C, Zhao H, Natarajan P. Elevated Blood Pressure Increases Pneumonia Risk: Epidemiological Association and Mendelian Randomization in the UK Biobank. Med (N Y). 2020 Nov 30. doi: 10.1016/j.medj.2020.11.001. Epub ahead of print. PMID: 33283203; PMCID: PMC7703520.

90. Small AM*, Huffman JE*, Klarin D, Lynch JA, Assimes T, DuVall S, Sun YV, Shere L, Natarajan P, Gaziano M, Rader DJ, Wilson PWF, Tsao PS, Chang KM, Cho K, O’Donnell CJ, Casas JP, Damrauer SM; VA Million Veteran Program. PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort. PLoS One. 2020 Nov 9;15(11):e0239752. doi: 10.1371/journal.pone.0239752. PMID: 33166319; PMCID: PMC7652310.

89. Berman AN, Biery DW, Ginder C, Hulme OL, Marcusa D, Leiva O, Wu WY, Singh A, Divakaran S, Hainer J, Turchin A, Januzzi JL, Natarajan P, Cannon CP, Di Carli MF, Bhatt DL, Blankstein R. Study of lipoprotein(a) and its impact on atherosclerotic cardiovascular disease: Design and rationale of the Mass General Brigham Lp(a) Registry. Clin Cardiol. 2020 Nov;43(11):1209-1215. doi: 10.1002/clc.23456. Epub 2020 Sep 6. PMID: 32893370; PMCID: PMC7661644.

88. Honigberg MC, Riise HKR, Daltveit AK, Tell GS, Sulo G, Igland J, Klungsøyr K, Scott NS, Wood MJ, Natarajan P, Rich-Edwards JW. Heart Failure in Women With Hypertensive Disorders of Pregnancy: Insights From the Cardiovascular Disease in Norway Project. Hypertension. 2020 Nov;76(5):1506-1513. doi: 10.1161/HYPERTENSIONAHA.120.15654. Epub 2020 Aug 24. PMID: 32829667; PMCID: PMC7544653.

87. Honigberg MC, Pirruccello JP, Aragam K, Sarma AA, Scott NS, Wood MJ, Natarajan P. Menopausal age and left ventricular remodeling by cardiac magnetic resonance imaging among 14,550 women. Am Heart J. 2020 Nov;229:138-143. doi: 10.1016/j.ahj.2020.08.005. Epub 2020 Aug 20. PMID: 32827459; PMCID: PMC7669696.

86. Klarin D, Verma SS, Judy R, Dikilitas O, Wolford BN, Paranjpe I, Levin MG, Pan C, Tcheandjieu C, Spin JM, Lynch J, Assimes TL, Åldstedt Nyrønning L, Mattsson E, Edwards TL, Denny J, Larson E, Lee MTM, Carrell D, Zhang Y, Jarvik GP, Gharavi AG, Harley J, Mentch F, Pacheco JA, Hakonarson H, Skogholt AH, Thomas L, Gabrielsen ME, Hveem K, Nielsen JB, Zhou W, Fritsche L, Huang J, Natarajan P, Sun YV, DuVall SL, Rader DJ, Cho K, Chang KM, Wilson PWF, O’Donnell CJ, Kathiresan S, Scali ST, Berceli SA, Willer C, Jones GT, Bown MJ, Nadkarni G, Kullo IJ, Ritchie M, Damrauer SM*, Tsao PS*; Veterans Affairs Million Veteran Program. Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program. Circulation. 2020 Oct 27;142(17):1633-1646. doi: 10.1161/CIRCULATIONAHA.120.047544. Epub 2020 Sep 28. PMID: 32981348; PMCID: PMC7580856.

85. Trinder M, Uddin MM, Finneran P, Aragam KG, Natarajan P. Clinical Utility of Lipoprotein(a) and LPA Genetic Risk Score in Risk Prediction of Incident Atherosclerotic Cardiovascular Disease. JAMA Cardiol. 2020 Oct 6:e205398. doi: 10.1001/jamacardio.2020.5398. Epub ahead of print. PMID: 33021622; PMCID: PMC7539232.

84. Bick AG*, Weinstock JS*, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, Chang K, Laurie C, Burugula BB, Gibson CJ, Lin AE, Taub MA, Aguet F, Ardlie K, Mitchell BD, Barnes KC, Moscati A, Fornage M, Redline S, Psaty BM, Silverman EK, Weiss ST, Palmer ND, Vasan RS, Burchard EG, Kardia SLR, He J, Kaplan RC, Smith NL, Arnett DK, Schwartz DA, Correa A, de Andrade M, Guo X, Konkle BA, Custer B, Peralta JM, Gui H, Meyers DA, McGarvey ST, Chen IY, Shoemaker MB, Peyser PA, Broome JG, Gogarten SM, Wang FF, Wong Q, Montasser ME, Daya M, Kenny EE, North KE, Launer LJ, Cade BE, Bis JC, Cho MH, Lasky-Su J, Bowden DW, Cupples LA, Mak ACY, Becker LC, Smith JA, Kelly TN, Aslibekyan S, Heckbert SR, Tiwari HK, Yang IV, Heit JA, Lubitz SA, Johnsen JM, Curran JE, Wenzel SE, Weeks DE, Rao DC, Darbar D, Moon JY, Tracy RP, Buth EJ, Rafaels N, Loos RJF, Durda P, Liu Y, Hou L, Lee J, Kachroo P, Freedman BI, Levy D, Bielak LF, Hixson JE, Floyd JS, Whitsel EA, Ellinor PT, Irvin MR, Fingerlin TE, Raffield LM, Armasu SM, Wheeler MM, Sabino EC, Blangero J, Williams LK, Levy BD, Sheu WH, Roden DM, Boerwinkle E, Manson JE, Mathias RA, Desai P, Taylor KD, Johnson AD; NHLBI Trans-Omics for Precision Medicine Consortium, Auer PL, Kooperberg C, Laurie CC, Blackwell TW, Smith AV, Zhao H, Lange E, Lange L, Rich SS, Rotter JI, Wilson JG, Scheet P, Kitzman JO, Lander ES, Engreitz JM, Ebert BL, Reiner AP, Jaiswal S, Abecasis G, Sankaran VG, Kathiresan S*, Natarajan P*. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020 Oct;586(7831):763-768. doi: 10.1038/s41586-020-2819-2. Epub 2020 Oct 14. PMID: 33057201.

83. Bao EL*, Nandakumar SK*, Liao X*, Bick AG, Karjalainen J, Tabaka M, Gan OI, Havulinna AS, Kiiskinen TTJ, Lareau CA, de Lapuente Portilla AL, Li B, Emdin C, Codd V, Nelson CP, Walker CJ, Churchhouse C, de la Chapelle A, Klein DE, Nilsson B, Wilson PWF, Cho K, Pyarajan S, Gaziano JM, Samani NJ; FinnGen; 23andMe Research Team, Regev A, Palotie A, Neale BM, Dick JE, Natarajan P, O’Donnell CJ, Daly MJ, Milyavsky M, Kathiresan S, Sankaran VG. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature. 2020 Oct;586(7831):769-775. doi: 10.1038/s41586-020-2786-7. Epub 2020 Oct 14. PMID: 33057200; PMCID: PMC7606745.

82. Nomura A*, Emdin CA*, Won HH, Peloso GM, Natarajan P, Ardissino D, Danesh J, Schunkert H, Correa A, Bown MJ, Samani NJ, Erdmann J, McPherson R, Watkins H, Saleheen D, Elosua R, Kawashiri MA, Tada H, Gupta N, Shah SH, Rader DJ, Gabriel S, Khera AV*, Kathiresan S*. Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease. Circ Genom Precis Med. 2020 Oct;13(5):417-423. doi: 10.1161/CIRCGEN.119.002871. Epub 2020 Aug 30. PMID: 32862661.

81. Narla A, Paruchuri K, Natarajan P. Digital health for primary prevention of cardiovascular disease: Promise to practice. Cardiovasc Digit Health J. 2020 Sep-Oct;1(2):59-61. doi: 10.1016/j.cvdhj.2020.09.002. Epub 2020 Sep 19. PMID: 32984862; PMCID: PMC7501772.

80. Ferraro NM, Strober BJ, Einson J, Abell NS, Aguet F, Barbeira AN, Brandt M, Bucan M, Castel SE, Davis JR, Greenwald E, Hess GT, Hilliard AT, Kember RL, Kotis B, Park Y, Peloso G, Ramdas S, Scott AJ, Smail C, Tsang EK, Zekavat SM, Ziosi M, Aradhana; TOPMed Lipids Working Group, Ardlie KG, Assimes TL, Bassik MC, Brown CD, Correa A, Hall I, Im HK, Li X, Natarajan P; GTEx Consortium, Lappalainen T, Mohammadi P, Montgomery SB, Battle A. Transcriptomic signatures across human tissues identify functional rare genetic variation. Science. 2020 Sep 11;369(6509):eaaz5900. doi: 10.1126/science.aaz5900. Epub 2020 Sep 10. PMID: 32913073.

79. Li X*, Li Z*, Zhou H, Gaynor SM, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Aslibekyan S, Ballantyne CM, Bielak LF, Blangero J, Boerwinkle E, Bowden DW, Broome JG, Conomos MP, Correa A, Cupples LA, Curran JE, Freedman BI, Guo X, Hindy G, Irvin MR, Kardia SLR, Kathiresan S, Khan AT, Kooperberg CL, Laurie CC, Liu XS, Mahaney MC, Manichaikul AW, Martin LW, Mathias RA, McGarvey ST, Mitchell BD, Montasser ME, Moore JE, Morrison AC, O’Connell JR, Palmer ND, Pampana A, Peralta JM, Peyser PA, Psaty BM, Redline S, Rice KM, Rich SS, Smith JA, Tiwari HK, Tsai MY, Vasan RS, Wang FF, Weeks DE, Weng Z, Wilson JG, Yanek LR; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Lipids Working Group, Neale BM, Sunyaev SR, Abecasis GR, Rotter JI, Willer CJ, Peloso GM, Natarajan P, Lin X. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet. 2020 Sep;52(9):969-983. doi: 10.1038/s41588-020-0676-4. Epub 2020 Aug 24. PMID: 32839606; PMCID: PMC7483769.

78. McCarthy CP, Murphy S, Jones-O’Connor M, Olshan DS, Khambhati JR, Rehman S, Cadigan JB, Cui J, Meyerowitz EA, Philippides G, Friedman LS, Kadar AY, Hibbert K, Natarajan P, Massaro AF, Bohula EA, Morrow DA, Woolley AE, Januzzi JL Jr, Wasfy JH. Early clinical and sociodemographic experience with patients hospitalized with COVID-19 at a large American healthcare system. EClinicalMedicine. 2020 Aug 19:100504. doi: 10.1016/j.eclinm.2020.100504. Epub ahead of print. PMID: 32838244; PMCID: PMC7434634.

77. Honigberg MC, Chaffin M, Aragam K, Bhatt DL, Wood MJ, Sarma AA, Scott NS, Peloso GM, Natarajan P. Genetic Variation in Cardiometabolic Traits and Medication Targets and the Risk of Hypertensive Disorders of Pregnancy. Circulation. 2020 Aug 18;142(7):711-713. doi: 10.1161/CIRCULATIONAHA.120.047936. Epub 2020 Aug 17. PMID: 32804569; PMCID: PMC7436942.

76. Berman AN, Biery DW, Singh A, Wu WY, Divakaran S, DeFilippis EM, Hainer J, Blaha MJ, Cannon C, Polk DM, Plutzky J, Natarajan P, Nasir K, Di Carli MF, Bhatt DL, Blankstein R. Atherosclerotic cardiovascular disease risk and elevated lipoprotein(a) among young adults with myocardial infarction: The Partners YOUNG-MI Registry. Eur J Prev Cardiol. 2020 Jun 15:2047487320931296. doi: 10.1177/2047487320931296. Epub ahead of print. PMID: 32539451.

75. Aragam KG*, Dobbyn A*, Judy R, Chaffin M, Chaudhary K, Hindy G, Cagan A, Finneran P, Weng LC, Loos RJF, Nadkarni G, Cho JH, Kember RL, Baras A, Reid J, Overton J, Philippakis A, Ellinor PT, Weiss ST, Rader DJ, Lubitz SA, Smoller JW, Karlson EW, Khera AV, Kathiresan S, Do R*, Damrauer SM*, Natarajan P*. Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease. J Am Coll Cardiol. 2020 Jun 9;75(22):2769-2780. doi: 10.1016/j.jacc.2020.04.027. PMID: 32498804; PMCID: PMC7346975.

74. Honigberg MC, Natarajan P. Women’s Cardiovascular Health After Hypertensive Pregnancy: The Long View From Labor and Delivery Becomes Clearer. J Am Coll Cardiol. 2020 May 12;75(18):2335-2337. doi: 10.1016/j.jacc.2020.01.064. PMID: 32381165.

73. Yang J, Biery DW, Singh A, Divakaran S, DeFilippis EM, Wu WY, Klein J, Hainer J, Ramsis M, Natarajan P, Januzzi JL, Nasir K, Bhatt DL, Di Carli MF, Blankstein R. Risk Factors and Outcomes of Very Young Adults Who Experience Myocardial Infarction: The Partners YOUNG-MI Registry. Am J Med. 2020 May;133(5):605-612.e1. doi: 10.1016/j.amjmed.2019.10.020. Epub 2019 Nov 9. PubMed PMID: 31715169.

72. Aragam KG, Natarajan P. Polygenic Scores to Assess Atherosclerotic Cardiovascular Disease Risk: Clinical Perspectives and Basic Implications. Circ Res. 2020 Apr 24;126(9):1159-1177. doi: 10.1161/CIRCRESAHA.120.315928. Epub 2020 Apr 23. PMID: 32324503.

71. Honigberg MC, Lander BS, Baliyan V, Jones-O’Connor M, Healy EW, Scholtz JE, Nagurney JT, Hoffmann U, Ghoshhajra BB, Natarajan P. Preventive Management of Nonobstructive CAD After Coronary CT Angiography in the Emergency Department. JACC Cardiovasc Imaging. 2020 Feb;13(2 Pt 1):437-448. doi: 10.1016/j.jcmg.2019.04.021. Epub 2019 Jul 17. PMID: 31326481; PMCID: PMC6954346.

70. Bick AG*, Pirruccello JP*, Griffin GK, Gupta N, Gabriel S, Saleheen D, Libby P, Kathiresan S, Natarajan P. Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis. Circulation. 2020 Jan 14;141(2):124-131. doi: 10.1161/CIRCULATIONAHA.119.044362. Epub 2019 Nov 11. PMID: 31707836; PMCID: PMC7008855.

69. Honigberg MC, Zekavat SM, Aragam K, Klarin D, Bhatt DL, Scott NS, Peloso GM, Natarajan P. Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy. J Am Coll Cardiol. 2019 Dec 3;74(22):2743-2754. doi: 10.1016/j.jacc.2019.09.052. Epub 2019 Nov 11. PubMed PMID: 31727424; PubMed Central PMCID: PMC6981240.

68. Honigberg MC, Zekavat SM, Aragam K, Finneran P, Klarin D, Januzzi JL, Scott NS, Natarajan P. Association of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease. JAMA. 2019 Nov 18;e1919191. doi: 10.1001/jama.2019.19191. [Epub ahead of print]. PubMed PMID: 31738818; PubMed Central PMCID: PMC6865332.

67. Honigberg MC, Natarajan P. Bempedoic Acid for Lowering LDL Cholesterol. JAMA. 2019 Nov 12;322(18):1769-1771. doi: 10.1001/jama.2019.16598. PMID: 31714973; PMCID: PMC6865332.

66. Lindstrom S, Wang L, Smith EN, Gordon W, van Hylckama Vlieg A, de Andrade M, Brody JA, Pattee JW, Haessler J, Brumpton BM, Chasman DI, Suchon P, Chen MH, Turman C, Germain M, Wiggins KL, MacDonald J, Braekkan SK, Armasu SM, Pankratz N, Jackson RD, Nielsen JB, Giulianini F, Puurunen MK, Ibrahim M, Heckbert SR, Damrauer SM, Natarajan P, Klarin D, de Vries PS, Sabater-Lleal M, Huffman JE, Bammler TK, Frazer KA, McCauley BM, Taylor K, Pankow JS, Reiner AP, Gabrielsen ME, Deleuze JF, O’Donnell CJ, Kim J, McKnight B, Kraft P, Hansen JB, Rosendaal FR, Heit JA, Psaty BM, Tang W, Kooperberg C, Hveem K, Ridker PM, Morange PE, Johnson AD, Kabrhel C, Trégouët DA, Smith NL. Genomic and Transcriptomic Association Studies Identify 16 Novel Susceptibility Loci for Venous Thromboembolism. Blood. 2019 Nov 7;134(19):1645-1657. doi: 10.1182/blood.2019000435. PubMed PMID: 31420334; PubMed Central PMCID: PMC6871304.

65. Klarin D, Busenkell E, Judy R, Lynch J, Levin M, Haessler J, Aragam K, Chaffin M, Haas M, Lindstrom S, Assimes TL, Huang J, Lee KM, Shao Q, Huffman JE, Kabrhel C, Huang Y, Sun YV, Vujkovic M, Saleheen D, Miller DR, Reaven P, DuVall S, Boden WE, Pyarajan S, Reiner AP, Tregouet D-A, Henke P, Kooperberg, Gaziano JM, Concato J, Rader DJ, Cho K, Chang K-M, Wilson PWF, Smith NL, O’Donnell CJ, Tsao PS, Kathiresan S, Obi A, Damrauer SM*, Natarajan P*, INVENT Consortium, VA Million Veteran Program. Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease. Nat Genet. 2019 Nov;51(11):1574-1579. doi: 10.1038/s41588-019-0519-3. Epub 2019 Nov 1. PubMed PMID: 31676865; PubMed Central: PMC6858581.

64. Patel AP, Natarajan P. A New Murine Model of Clonal Hematopoiesis Investigates JAK2V617Fin Heart Failure. JACC Basic Transl Sci. 2019 Oct 28;4(6):698-700. doi: 10.1016/j.jacbts.2019.09.003. PMID: 31713537; PMCID: PMC6834939.

63. Bick AG*, Akwo E*, Robinson-Cohen C*, Lee K, Lynch J, Assimes TL, DuVall S, Edwards T, Fang H, Freiberg SM, Giri A, Huffman JE, Huang J, Hull L, Kember RL, Klarin D, Lee JS, Levin M, Miller DR, Natarajan P, Saleheen D, Shao Q, Sun YV, Tang H, Wilson O, Chang KM, Cho K, Concato J, Gaziano JM, Kathiresan S, O’Donnell CJ, Rader DJ, Tsao PS, Wilson PW, Hung AM, Damrauer SM; VA Million Veteran Program. Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program. Circulation. 2019 Sep 17;140(12):1031-1040. doi: 10.1161/CIRCULATIONAHA.118.036589. Epub 2019 Jul 24. PubMed PMID: 31337231; PubMed Central: PMC6754626.

62. Klarin D, Lynch J, Aragam K, Chaffin M, Assimes TL, Huang J, Lee KM, Shao Q, Huffman JE, Natarajan P, Arya S, Small A, Sun YV, Vujkovic M, Freiberg MS, Wang L, Chen J, Saleheen D, Lee JS, Miller DR, Reaven P, Alba PR, Patterson OV, DuVall SL, Boden WE, Beckman JA, Gaziano JM, Concato J, Rader DJ, Cho K, Chang KM, Wilson PWF, O’Donnell CJ, Kathiresan S; VA Million Veteran Program, Tsao PS*, Damrauer SM*. Genome-wide association study of peripheral artery disease in the Million Veteran Program. Nat Med. 2019 Aug;25(8):1274-1279. doi: 10.1038/s41591-019-0492-5. Epub 2019 Jul 8. PubMed PMID: 31285632; PubMed Central PMCID: PMC6768096.

61. Khetarpal SA, Qamar A, Bick AG, Fuster JJ, Kathiresan S, Jaiswal S, Natarajan P. Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week. J Am Coll Cardiol. 2019 Jul 30;74(4):578-586. doi: 10.1016/j.jacc.2019.05.045. Review. PubMed PMID: 31345433; PubMed Central PMCID: PMC6662618.

60. Jones-O’Connor M, Natarajan P. Optimal Non-invasive Strategies to Reduce Recurrent Atherosclerotic Cardiovascular Disease Risk. Curr Treat Options Cardiovasc Med. 2019 Jun 29;21(8):38. doi: 10.1007/s11936-019-0741-4. Review. PubMed PMID: 31254118; PubMed Central: PMC6739861.

59. Zekavat SM, Roselli C, Hindy G, Lubitz SA, Ellinor PT, Zhao H, Natarajan P. Genetic Link Between Arterial Stiffness and Atrial Fibrillation. Circ Genom Precis Med. 2019 Jun;12(6):e002453. doi: 10.1161/CIRCGEN.118.002453. Epub 2019 Jun 18. PMID: 31211625; PMCID: PMC6582989.

58. Zekavat SM, Aragam K, Emdin C, Khera AV, Klarin D, Zhao H, Natarajan P. Genetic Association of Finger Photoplethysmography-Derived Arterial Stiffness Index With Blood Pressure and Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1253-1261. doi: 10.1161/ATVBAHA.119.312626. PubMed PMID: 31070453; PubMed Central PMCID: PMC6531323.

57. Natarajan P, Collier TS, Jin Z, Lyass A, Li Y, Ibrahim NE, Mukai R, McCarthy CP, Massaro JM, D’Agostino RB Sr, Gaggin HK, Bystrom C, Penn MS, Januzzi JL Jr. Association of an HDL Apolipoproteomic Score With Coronary Atherosclerosis and Cardiovascular Death. J Am Coll Cardiol. 2019 May 7;73(17):2135-2145. doi: 10.1016/j.jacc.2019.01.073. PubMed PMID: 31047001; PubMed Central PMCID: PMC6501819.

56. Alver M, Palover M, Saar A, Läll K, Zekavat SM, Tõnisson N, Leitsalu L, Reigo A, Nikopensius T, Ainla T, Kals M, Mägi R, Gabriel SB, Eha J, Lander ES, Irs A, Philippakis A, Marandi T, Natarajan P, Metspalu A, Kathiresan S, Esko T. Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia. Genet Med. 2019 May;21(5):1173-1180. doi: 10.1038/s41436-018-0311-2. Epub 2018 Oct 1. PMID: 30270359; PMCID: PMC6443485.

55. Patel AP, Natarajan P. Completing the genetic spectrum influencing coronary artery disease: from germline to somatic variation. Cardiovasc Res. 2019 Apr 15;115(5):830-843. doi: 10.1093/cvr/cvz032. PubMed PMID: 30789660; PubMed Central PMCID: PMC6452301.

54. Khera AV*, Chaffin M*, Zekavat SM, Collins RL, Roselli C, Natarajan P, Lichtman JH, D’Onofrio G, Mattera J, Dreyer R, Spertus JA, Taylor KD, Psaty BM, Rich SS, Post W, Gupta N, Gabriel S, Lander E, Ida Chen YD, Talkowski ME, Rotter JI, Krumholz HM*, Kathiresan S*. Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction. Circulation. 2019 Mar 26;139(13):1593-1602. doi: 10.1161/CIRCULATIONAHA.118.035658. PubMed PMID: 30586733; PubMed Central PMCID: PMC6433484.

53. Hu Y*, Li M*, Lu Q*, Weng H, Wang J, Zekavat SM, Yu Z, Li B, Gu J, Muchnik S, Shi Y, Kunkle BW, Mukherjee S, Natarajan P, Naj A, Kuzma A, Zhao Y, Crane PK; Alzheimer’s Disease Genetics Consortium,, Lu H, Zhao H. A statistical framework for cross-tissue transcriptome-wide association analysis. Nat Genet. 2019 Mar;51(3):568-576. doi: 10.1038/s41588-019-0345-7. Epub 2019 Feb 25. PMID: 30804563; PMCID: PMC6788740.

52. Emdin CA, Khera AV, Aragam K, Haas M, Chaffin M, Klarin D, Natarajan P, Bick A, Zekavat SM, Nomura A, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gupta N, Danesh J, Saleheen D, Gabriel S, Kathiresan S. DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes. Diabetes. 2019 Jan;68(1):226-234. doi: 10.2337/db18-0857. Epub 2018 Nov 2. PMID: 30389748; PMCID: PMC6302541.

51. Sun YV, Damrauer SM, Hui Q, Assimes TL, Ho YL, Natarajan P, Klarin D, Huang J, Lynch J, DuVall SL, Pyarajan S, Honerlaw JP, Gaziano JM, Cho K, Rader DJ, O’Donnell CJ, Tsao PS, Wilson PWF. Effects of Genetic Variants Associated with Familial Hypercholesterolemia on Low-Density Lipoprotein-Cholesterol Levels and Cardiovascular Outcomes in the Million Veteran Program. Circ Genom Precis Med. 2018 Dec;11(12). pii: e002192. doi: 10.1161/CIRCGEN.118.002192. PubMed PMID: 31106297; PubMed Central PMCID: PMC6516478.

50. Klarin D*, Damrauer SM*, Cho K, Sun YV, Teslovich TM, Honerlaw J, Gagnon DR, DuVall SL, Li J, Peloso GM, Chaffin M, Small AM, Huang J, Tang H, Lynch JA, Ho YL, Liu DJ, Emdin CA, Li AH, Huffman JE, Lee JS, Natarajan P, Chowdhury R, Saleheen D, Vujkovic M, Baras A, Pyarajan S, Di Angelantonio E, Neale BM, Naheed A, Khera AV, Danesh J, Chang KM, Abecasis G, Willer C, Dewey FE, Carey DJ; Global Lipids Genetics Consortium; Myocardial Infarction Genetics (MIGen) Consortium; Geisinger-Regeneron DiscovEHR Collaboration; VA Million Veteran Program, Concato J, Gaziano JM, O’Donnell CJ*, Tsao PS*, Kathiresan S*, Rader DJ*, Wilson PWF*, Assimes TL*. Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. Nat Genet. 2018 Nov;50(11):1514-1523. doi: 10.1038/s41588-018-0222-9. Epub 2018 Oct 1. PMID: 30275531; PMCID: PMC6521726.

49. Natarajan P. Polygenic Risk Scoring for Coronary Heart Disease: The First Risk Factor. J Am Coll Cardiol. 2018 Oct 16;72(16):1894-1897. doi: 10.1016/j.jacc.2018.08.1041. PubMed PMID: 30309465; PubMed Central PMCID: PMC6215449.

48. Johnson SW, Hedgire SS, Scott NS, Natarajan P. Spontaneous coronary artery dissection masquerading as Takotsubo cardiomyopathy: a case report. Eur Heart J Case Rep. 2018 Oct 11;2(4):yty102. doi: 10.1093/ehjcr/yty102. eCollection 2018 Dec. PubMed PMID: 31020178; PubMed Central PMCID: PMC6426097.

47. Khera AV*, Chaffin M*, Aragam KG, Haas ME, Roselli C, Choi SH, Natarajan P, Lander ES, Lubitz SA, Ellinor PT, Kathiresan S. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z. Epub 2018 Aug 13. PubMed PMID: 30104762; PubMed Central PMCID: PMC6128408.

46. Natarajan P*, Peloso GM*, Zekavat SM*, Montasser M, Ganna A, Chaffin M, Khera AV, Zhou W, Bloom JM, Engreitz JM, Ernst J, O’Connell JR, Ruotsalainen SE, Alver M, Manichaikul A, Johnson WC, Perry JA, Poterba T, Seed C, Surakka IL, Esko T, Ripatti S, Salomaa V, Correa A, Vasan RS, Kellis M, Neale BM, Lander ES, Abecasis G, Mitchell B, Rich SS, Wilson JG, Cupples LA, Rotter JI, Willer CJ*, Kathiresan S*; NHLBI TOPMed Lipids Working Group. Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nat Commun. 2018 Aug 23;9(1):3391. doi: 10.1038/s41467-018-05747-8. PubMed PMID: 30140000; PubMed Central PMCID: PMC6107638.

45. Zekavat SM, Ruotsalainen S, Handsaker RE, Alver M, Bloom J, Poterba T, Seed C, Ernst J, Chaffin M, Engreitz J, Peloso GM, Manichaikul A, Yang C, Ryan KA, Fu M, Johnson WC, Tsai M, Budoff M, Ramachandran VS, Cupples LA, Rotter JI, Rich SS, Post W, Mitchell BD, Correa A, Metspalu A, Wilson JG, Salomaa V, Kellis M, Daly MJ, Neale BM, McCarroll S, Surakka I, Esko T*, Ganna A*, Ripatti S*, Kathiresan S*, Natarajan P*; NHLBI TOPMed Lipids Working Group. Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018 Jul 4;9(1):2606. doi: 10.1038/s41467-018-04668-w. PubMed PMID: 29973585; PubMed Central PMCID: PMC6031652.

44. Natarajan P, Jaiswal S, Kathiresan S. Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis. Circ Genom Precis Med. 2018 Jul;11(7):e001926. doi: 10.1161/CIRCGEN.118.001926. Review. PubMed PMID: 29987111; PubMed Central PMCID: PMC6082163.

43. Gusarova V*, O’Dushlaine C*, Teslovich TM*, Benotti PN, Mirshahi T, Gottesman O, Van Hout CV, Murray MF, Mahajan A, Nielsen JB, Fritsche L, Wulff AB, Gudbjartsson DF, Sjögren M, Emdin CA, Scott RA, Lee WJ, Small A, Kwee LC, Dwivedi OP, Prasad RB, Bruse S, Lopez AE, Penn J, Marcketta A, Leader JB, Still CD, Kirchner HL, Mirshahi UL, Wardeh AH, Hartle CM, Habegger L, Fetterolf SN, Tusie-Luna T, Morris AP, Holm H, Steinthorsdottir V, Sulem P, Thorsteinsdottir U, Rotter JI, Chuang LM, Damrauer S, Birtwell D, Brummett CM, Khera AV, Natarajan P, Orho-Melander M, Flannick J, Lotta LA, Willer CJ, Holmen OL, Ritchie MD, Ledbetter DH, Murphy AJ, Borecki IB, Reid JG, Overton JD, Hansson O, Groop L, Shah SH, Kraus WE, Rader DJ, Chen YI, Hveem K, Wareham NJ, Kathiresan S, Melander O, Stefansson K, Nordestgaard BG, Tybjærg-Hansen A, Abecasis GR, Altshuler D, Florez JC, Boehnke M, McCarthy MI, Yancopoulos GD, Carey DJ, Shuldiner AR, Baras A*, Dewey FE*, Gromada J*. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nat Commun. 2018 Jun 13;9(1):2252. doi: 10.1038/s41467-018-04611-z. PubMed PMID: 29899519; PubMed Central PMCID: PMC5997992.

42. Peloso GM, Natarajan P. Insights from population-based analyses of plasma lipids across the allele frequency spectrum. Curr Opin Genet Dev. 2018 Jun;50:1-6. doi: 10.1016/j.gde.2018.01.003. Epub 2018 Feb 13. PMID: 29448166; PMCID: PMC6087690.

41. Emdin CA*, Khera AV*, Chaffin M, Klarin D, Natarajan P, Aragam K, Haas M, Bick A, Zekavat SM, Nomura A, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gupta N, Danesh J, Chasman D, Ridker P, Denny J, Bastarache L, Lichtman JH, D’Onofrio G, Mattera J, Spertus JA, Sheu WH, Taylor KD, Psaty BM, Rich SS, Post W, Rotter JI, Chen YI, Krumholz H, Saleheen D, Gabriel S, Kathiresan S. Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease. Nat Commun. 2018 Apr 24;9(1):1613. doi: 10.1038/s41467-018-03911-8. PubMed PMID: 29691411; PubMed Central PMCID: PMC5915445.

40. Emdin CA, Khera AV, Klarin D, Natarajan P, Zekavat SM, Nomura A, Haas ME, Aragam K, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gormley P, Palotie A, Stitziel N, Gupta N, Danesh JN, Saleheen D, Gabriel SB, Kathiresan S. Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling. Circulation. 2018 Jan 16;137(3):222-232. doi: 10.1161/CIRCULATIONAHA.117.028021. Epub 2017 Oct 5. PubMed PMID: 28982690; PubMed Central PMCID: PMC5771958.

39. Hess GP, Natarajan P, Faridi KF, Fievitz A, Valsdottir L, Yeh RW. Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Therapy: Payer Approvals and Rejections, and Patient Characteristics for Successful Prescribing. Circulation. 2017 Dec 5;136(23):2210-2219. doi: 10.1161/CIRCULATIONAHA.117.028430. Epub 2017 Oct 30. PubMed PMID: 29084735; PubMed Central PMCID: PMC5716860.

38. Jaiswal S, Natarajan P, Ebert BL. Clonal Hematopoiesis and Atherosclerosis. N Engl J Med. 2017 Oct 5;377(14):1401-1402. doi: 10.1056/NEJMc1710381. PubMed PMID: 28976867.

37. Khetarpal SA, Zeng X, Millar JS, Vitali C, Somasundara AVH, Zanoni P, Landro JA, Barucci N, Zavadoski WJ, Sun Z, de Haard H, Toth IV, Peloso GM, Natarajan P, Cuchel M, Lund-Katz S, Phillips MC, Tall AR, Kathiresan S, DaSilva-Jardine P, Yates NA, Rader DJ. A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nat Med. 2017 Sep;23(9):1086-1094. doi: 10.1038/nm.4390. Epub 2017 Aug 21. PubMed PMID: 28825717; PubMed Central PMCID: PMC5669375.

36. Klarin D*, Zhu QM*, Emdin CA, Chaffin M, Horner S, McMillan BJ, Leed A, Weale ME, Spencer CCA, Aguet F, Segrè AV, Ardlie KG, Khera AV, Kaushik VK, Natarajan P; CARDIoGRAMplusC4D Consortium, Kathiresan S. Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease. Nat Genet. 2017 Sep;49(9):1392-1397. doi: 10.1038/ng.3914. Epub 2017 Jul 17. PubMed PMID: 28714974; PubMed Central PMCID: PMC5577383.

35. Emdin CA, Klarin D, Natarajan P; CARDIOGRAM Exome Consortium, Florez JC, Kathiresan S, Khera AV. Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease. Diabetes. 2017 Aug;66(8):2310-2315. doi: 10.2337/db17-0149. Epub 2017 Apr 14. PubMed PMID: 28411266; PubMed Central PMCID: PMC5521864.

34. Jaiswal S, Natarajan P, Silver AJ, Gibson CJ, Bick AG, Shvartz E, McConkey M, Gupta N, Gabriel S, Ardissino D, Baber U, Mehran R, Fuster V, Danesh J, Frossard P, Saleheen D, Melander O, Sukhova GK, Neuberg D, Libby P, Kathiresan S*, Ebert BL*. Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. N Engl J Med. 2017 Jul 13;377(2):111-121. doi: 10.1056/NEJMoa1701719. Epub 2017 Jun 21. PMID: 28636844; PMCID: PMC6717509.

33. Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartze DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JJ, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer CJ, Abecasis GR, Saleheen D, Kubo M, Kato N, Ida Chen YD, Dewey FE, Kathiresan S. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res. 2017 Jun 23;121(1):81-88. doi: 10.1161/CIRCRESAHA.117.311145. Epub 2017 May 15. PubMed PMID: 28506971; PubMed Central PMCID: PMC5523940.

32. Pirruccello JP, Traynor KC, Natarajan P, Brown C, Hidrue MK, Rosenfield KA, Kathiresan S, Wasfy JH. An electronic cardiac rehabilitation referral system increases cardiac rehabilitation referrals. Coron Artery Dis. 2017 Jun;28(4):342-345. doi: 10.1097/MCA.0000000000000491. PubMed PMID: 28346284.

31. Natarajan P*, Young R*, Stitziel NO, Padmanabhan S, Baber U, Mehran R, Sartori S, Fuster V, Reilly DF, Butterworth A, Rader DJ, Ford I*, Sattar N*, Kathiresan S*. Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting. Circulation. 2017 May 30;135(22):2091-2101. doi: 10.1161/CIRCULATIONAHA.116.024436. Epub 2017 Feb 21. PubMed PMID: 28223407; PubMed Central PMCID: PMC5484076.

30. Stitziel NO*, Khera AV*, Wang X*, Bierhals AJ, Vourakis AC, Sperry AE, Natarajan P, Klarin D, Emdin CA, Zekavat SM, Nomura A, Erdmann J, Schunkert H, Samani NJ, Kraus WE, Shah SH, Yu B, Boerwinkle E, Rader DJ, Gupta N, Frossard PM, Rasheed A, Danesh J, Lander ES, Gabriel S, Saleheen D*, Musunuru K*, Kathiresan S*; PROMIS and Myocardial Infarction Genetics Consortium Investigators. ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. J Am Coll Cardiol. 2017 Apr 25;69(16):2054-2063. doi: 10.1016/j.jacc.2017.02.030. Epub 2017 Apr 3. PubMed PMID: 28385496; PubMed Central PMCID: PMC5404817.

29. Saleheen D*, Natarajan P*, Armean IM, Zhao W, Rasheed A, Khetarpal SA, Won HH, Karczewski KJ, O’Donnell-Luria AH, Samocha KE, Weisburd B, Gupta N, Zaidi M, Samuel M, Imran A, Abbas S, Majeed F, Ishaq M, Akhtar S, Trindade K, Mucksavage M, Qamar N, Zaman KS, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Hayyat Mallick N, Ishaq M, Rasheed SZ, Memon FU, Mahmood K, Ahmed N, Do R, Krauss RM, MacArthur DG, Gabriel S, Lander ES, Daly MJ, Frossard P*, Danesh J*, Rader DJ*, Kathiresan S*. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 2017 Apr 12;544(7649):235-239. doi: 10.1038/nature22034. PubMed PMID: 28406212; PubMed Central PMCID: PMC5600291.

28. Klarin D, Emdin CA, Natarajan P, Conrad MF; INVENT Consortium, Kathiresan S. Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. Circ Cardiovasc Genet. 2017 Apr;10(2). pii: e001643. doi: 10.1161/CIRCGENETICS.116.001643. PubMed PMID: 28373160; PubMed Central PMCID: PMC5395047.

27. Emdin CA*, Khera AV*, Natarajan P, Klarin D, Baber U, Mehran R, Rader DJ, Fuster V, Kathiresan S. Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort. Am J Cardiol. 2017 Mar 15;119(6):881-885. doi: 10.1016/j.amjcard.2016.11.042. Epub 2016 Dec 18. PubMed PMID: 28061997.

26. Khera AV*, Won HH*, Peloso GM, O’Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer C, Abecasis GR, Saleheen D, Dewey FE, Kathiresan S; Myocardial Infarction Genetics Consortium, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium. Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. JAMA. 2017 Mar 7;317(9):937-946. doi: 10.1001/jama.2017.0972. PubMed PMID: 28267856; PubMed Central PMCID: PMC5664181.

25. Emdin CA*, Khera AV*, Natarajan P, Klarin D, Zekavat SM, Hsiao AJ, Kathiresan S. Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease. JAMA. 2017 Feb 14;317(6):626-634. doi: 10.1001/jama.2016.21042. PubMed PMID: 28196256; PubMed Central PMCID: PMC5571980.

24. Guo MH*, Nandakumar SK*, Ulirsch JC, Zekavat SM, Buenrostro JD, Natarajan P, Salem RM, Chiarle R, Mitt M, Kals M, Pärn K, Fischer K, Milani L, Mägi R, Palta P, Gabriel SB, Metspalu A, Lander ES, Kathiresan S, Hirschhorn JN, Esko T, Sankaran VG. Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E327-E336. doi: 10.1073/pnas.1619052114. Epub 2016 Dec 28. PubMed PMID: 28031487; PubMed Central PMCID: PMC5255587.

23. Emdin CA*, Khera AV*, Natarajan P, Klarin D, Won HH, Peloso GM, Stitziel NO, Nomura A, Zekavat SM, Bick AG, Gupta N, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Willer C, Abecasis GR, Felix JF, Vasan RS, Lander E, Rader DJ, Danesh J, Ardissino D, Gabriel S, Saleheen D, Kathiresan S; CHARGE–Heart Failure Consortium; CARDIoGRAM Exome Consortium. Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J Am Coll Cardiol. 2016 Dec 27;68(25):2761-2772. doi: 10.1016/j.jacc.2016.10.033. PubMed PMID: 28007139; PubMed Central PMCID: PMC5328146.

22. Khera AV*, Emdin CA*, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N Engl J Med. 2016 Dec 15;375(24):2349-2358. doi: 10.1056/NEJMoa1605086. Epub 2016 Nov 13. PubMed PMID: 27959714; PubMed Central PMCID: PMC5338864.

21. Natarajan P*, Bis JC*, Bielak LF, Cox AJ, Dörr M, Feitosa MF, Franceschini N, Guo X, Hwang SJ, Isaacs A, Jhun MA, Kavousi M, Li-Gao R, Lyytikäinen LP, Marioni RE, Schminke U, Stitziel NO, Tada H, van Setten J, Smith AV, Vojinovic D, Yanek LR, Yao J, Yerges-Armstrong LM, Amin N, Baber U, Borecki IB, Carr JJ, Chen YI, Cupples LA, de Jong PA, de Koning H, de Vos BD, Demirkan A, Fuster V, Franco OH, Goodarzi MO, Harris TB, Heckbert SR, Heiss G, Hoffmann U, Hofman A, Išgum I, Jukema JW, Kähönen M, Kardia SL, Kral BG, Launer LJ, Massaro J, Mehran R, Mitchell BD, Mosley TH Jr, de Mutsert R, Newman AB, Nguyen KD, North KE, O’Connell JR, Oudkerk M, Pankow JS, Peloso GM, Post W, Province MA, Raffield LM, Raitakari OT, Reilly DF, Rivadeneira F, Rosendaal F, Sartori S, Taylor KD, Teumer A, Trompet S, Turner ST, Uitterlinden AG, Vaidya D, van der Lugt A, Völker U, Wardlaw JM, Wassel CL, Weiss S, Wojczynski MK, Becker DM, Becker LC, Boerwinkle E, Bowden DW, Deary IJ, Dehghan A, Felix SB, Gudnason V, Lehtimäki T, Mathias R, Mook-Kanamori DO, Psaty BM, Rader DJ, Rotter JI, Wilson JG, van Duijn CM, Völzke H, Kathiresan S, Peyser PA, O’Donnell CJ; CHARGE Consortium. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016 Dec;9(6):511-520. doi: 10.1161/CIRCGENETICS.116.001572. Epub 2016 Nov 21. PubMed PMID: 27872105; PubMed Central PMCID: PMC5418659.

20. Ganna A*, Genovese G*, Howrigan DP, Byrnes A, Kurki M, Zekavat SM, Whelan CW, Kals M, Nivard MG, Bloemendal A, Bloom JM, Goldstein JI, Poterba T, Seed C, Handsaker RE, Natarajan P, Mägi R, Gage D, Robinson EB, Metspalu A, Salomaa V, Suvisaari J, Purcell SM, Sklar P, Kathiresan S, Daly MJ, McCarroll SA, Sullivan PF, Palotie A, Esko T, Hultman C, Neale BM. Ultra-rare disruptive and damaging mutations influence educational attainment in the general population. Nat Neurosci. 2016 Dec;19(12):1563-1565. doi: 10.1038/nn.4404. Epub 2016 Oct 3. PubMed PMID: 27694993; PubMed Central PMCID: PMC5127781.

19. Natarajan P*, Gold NB*, Bick AG*, McLaughlin H, Kraft P, Rehm HL, Peloso GM, Wilson JG, Correa A, Seidman JG, Seidman CE, Kathiresan S*, Green RC*. Aggregate penetrance of genomic variants for actionable disorders in European and African Americans. Sci Transl Med. 2016 Nov 9;8(364):364ra151. doi: 10.1126/scitranslmed.aag2367. PMID: 27831900; PMCID: PMC5823271.

18. Lin H, Mueller-Nurasyid M, Smith AV, Arking DE, Barnard J, Bartz TM, Lunetta KL, Lohman K, Kleber ME, Lubitz SA, Geelhoed B, Trompet S, Niemeijer MN, Kacprowski T, Chasman DI, Klarin D, Sinner MF, Waldenberger M, Meitinger T, Harris TB, Launer LJ, Soliman EZ, Chen LY, Smith JD, Van Wagoner DR, Rotter JI, Psaty BM, Xie Z, Hendricks AE, Ding J, Delgado GE, Verweij N, van der Harst P, Macfarlane PW, Ford I, Hofman A, Uitterlinden A, Heeringa J, Franco OH, Kors JA, Weiss S, Völzke H, Rose LM, Natarajan P, Kathiresan S, Kääb S, Gudnason V, Alonso A, Chung MK, Heckbert SR, Benjamin EJ, Liu Y, März W, Rienstra M, Jukema JW, Stricker BH, Dörr M, Albert CM, Ellinor PT. Gene-gene Interaction Analyses for Atrial Fibrillation. Sci Rep. 2016 Nov 8;6:35371. doi: 10.1038/srep35371. PubMed PMID: 27824142; PubMed Central PMCID: PMC5099695.

17. Lek M, Karczewski KJ*, Minikel EV*, Samocha KE*, Banks E, Fennell T, O’Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, Zhao F, Zou J, Pierce-Hoffman E, Berghout J, Cooper DN, Deflaux N, DePristo M, Do R, Flannick J, Fromer M, Gauthier L, Goldstein J, Gupta N, Howrigan D, Kiezun A, Kurki MI, Moonshine AL, Natarajan P, Orozco L, Peloso GM, Poplin R, Rivas MA, Ruano-Rubio V, Rose SA, Ruderfer DM, Shakir K, Stenson PD, Stevens C, Thomas BP, Tiao G, Tusie-Luna MT, Weisburd B, Won HH, Yu D, Altshuler DM, Ardissino D, Boehnke M, Danesh J, Donnelly S, Elosua R, Florez JC, Gabriel SB, Getz G, Glatt SJ, Hultman CM, Kathiresan S, Laakso M, McCarroll S, McCarthy MI, McGovern D, McPherson R, Neale BM, Palotie A, Purcell SM, Saleheen D, Scharf JM, Sklar P, Sullivan PF, Tuomilehto J, Tsuang MT, Watkins HC, Wilson JG, Daly MJ, MacArthur DG; Exome Aggregation Consortium. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 2016 Aug 18;536(7616):285-91. doi: 10.1038/nature19057. PubMed PMID: 27535533; PubMed Central PMCID: PMC5018207.

16. Khera AV, Natarajan P, Kathiresan S. The future of low-density lipoprotein cholesterol lowering therapy: An end to statin exceptionalism? Eur J Prev Cardiol. 2016 Jul;23(10):1062-4. doi: 10.1177/2047487315600818. Epub 2015 Aug 12. PMID: 26268264; PMCID: PMC6344937.

15. Khera AV*, Won HH*, Peloso GM*, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N, Nomura A, Kessler T, Duga S, Bis JC, van Duijn CM, Cupples LA, Psaty B, Rader DJ, Danesh J, Schunkert H, McPherson R, Farrall M, Watkins H, Lander E, Wilson JG, Correa A, Boerwinkle E, Merlini PA, Ardissino D, Saleheen D, Gabriel S, Kathiresan S. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol. 2016 Jun 7;67(22):2578-89. doi: 10.1016/j.jacc.2016.03.520. Epub 2016 Apr 3. PubMed PMID: 27050191; PubMed Central PMCID: PMC5405769.

14. Natarajan P, Kathiresan S. PCSK9 Inhibitors. Cell. 2016 May 19;165(5):1037. doi: 10.1016/j.cell.2016.05.016. PubMed PMID: 27203103.

13. Natarajan P, O’Donnell CJ. Reducing Cardiovascular Risk Using Genomic Information in the Era of Precision Medicine. Circulation. 2016 Mar 22;133(12):1155-9. doi: 10.1161/CIRCULATIONAHA.116.021765. Epub 2016 Feb 25. PubMed PMID: 26915631; PubMed Central PMCID: PMC4803573.

12. Clapham KR, Chu AY, Wessel J, Natarajan P, Flannick J, Rivas MA, Sartori S, Mehran R, Baber U, Fuster V, Scott RA, Rader DJ, Boehnke M, McCarthy MI, Altshuler DM, Kathiresan S, Peloso GM. A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans. BMC Endocr Disord. 2016 Jan 28;16:7. doi: 10.1186/s12902-016-0088-8. PubMed PMID: 26822414; PubMed Central PMCID: PMC4730725.

11. Natarajan P, Kohli P, Baber U, Nguyen KH, Sartori S, Reilly DF, Mehran R, Muntendam P, Fuster V, Rader DJ, Kathiresan S. Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study. J Am Coll Cardiol. 2015 Nov 3;66(18):2053-2055. doi: 10.1016/j.jacc.2015.08.866. PubMed PMID: 26516010; PubMed Central PMCID: PMC4706229.

10. Won HH, Natarajan P, Dobbyn A, Jordan DM, Roussos P, Lage K, Raychaudhuri S, Stahl E, Do R. Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease. PLoS Genet. 2015 Oct 28;11(10):e1005622. doi: 10.1371/journal.pgen.1005622. eCollection 2015 Oct. PubMed PMID: 26509271; PubMed Central PMCID: PMC4625039.

9. Myocardial Infarction Genetics Consortium Investigators, Stitziel NO*, Won HH*, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, Asselta R, Merlini PA, Marziliano N, Notarangelo MF, Schick U, Auer P, Assimes TL, Reilly M, Wilensky R, Rader DJ, Hovingh GK, Meitinger T, Kessler T, Kastrati A, Laugwitz KL, Siscovick D, Rotter JI, Hazen SL, Tracy R, Cresci S, Spertus J, Jackson R, Schwartz SM, Natarajan P, Crosby J, Muzny D, Ballantyne C, Rich SS, O’Donnell CJ, Abecasis G, Sunaev S, Nickerson DA, Buring JE, Ridker PM, Chasman DI, Austin E, Kullo IJ, Weeke PE, Shaffer CM, Bastarache LA, Denny JC, Roden DM, Palmer C, Deloukas P, Lin DY, Tang ZZ, Erdmann J, Schunkert H, Danesh J, Marrugat J, Elosua R, Ardissino D, McPherson R, Watkins H, Reiner AP, Wilson JG, Altshuler D, Gibbs RA, Lander ES, Boerwinkle E, Gabriel S, Kathiresan S. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med. 2014 Nov 27;371(22):2072-82. doi: 10.1056/NEJMoa1405386. Epub 2014 Nov 12. PubMed PMID: 25390462; PubMed Central PMCID: PMC4335708.

8. Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1788-94. doi: 10.1161/ATVBAHA.113.301300. Epub 2013 May 30. PubMed PMID: 23723371; PubMed Central PMCID: PMC3794714.

7. Natarajan P, Cannon CP. Myocardial infarction vaccine? Evidence supporting the influenza vaccine for secondary prevention. Eur Heart J. 2011 Jul;32(14):1701-3. doi: 10.1093/eurheartj/ehr053. Epub 2011 Mar 15. PubMed PMID: 21406438.

6.Natarajan P, Cannon CP. Could direct inhibition of inflammation be the “next big thing” in treating atherosclerosis? Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2081-3. doi: 10.1161/ATVBAHA.110.213793. PubMed PMID: 20962294.

5. Natarajan P, Ray KK, Cannon CP. High-density lipoprotein and coronary heart disease: current and future therapies. J Am Coll Cardiol. 2010 Mar 30;55(13):1283-99. doi: 10.1016/j.jacc.2010.01.008. Review. PubMed PMID: 20338488.

4. Natarajan P, Ranji SR, Auerbach AD, Hauer KE. Effect of hospitalist attending physicians on trainee educational experiences: a systematic review. J Hosp Med. 2009 Oct;4(8):490-8. doi: 10.1002/jhm.537. Review. PubMed PMID: 19824099.

3. Saxena V, Natarajan P, O’Sullivan PS, Jain S. Effect of the use of instructional anatomy videos on student performance. Anat Sci Educ. 2008 Jul-Aug;1(4):159-65. doi: 10.1002/ase.38. PubMed PMID: 19177403.

2. Natarajan P, Forte TM, Chu B, Phillips MC, Oram JF, Bielicki JK. Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1. J Biol Chem. 2004 Jun 4;279(23):24044-52. Epub 2004 Mar 29. doi: 10.1074/jbc.M400561200. PubMed PMID: 15051721.

1. Jia Z, Natarajan P, Forte TM, Bielicki JK. Thiol-bearing synthetic peptides retain the antioxidant activity of apolipoproteinA-I(Milano). Biochem Biophys Res Commun. 2002 Sep 20;297(2):206-13. doi: 10.1016/S0006-291X(02)02143-5. PubMed PMID: 12237103.

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