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2-15-24 Congrats Dr. Aeron Small on your recent publication in JAMA Cardiology. Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations.

1-17-24 Welcome 2024! Congrats Dr. Romit Bhattacharya! Risk Factors for Clonal Hematopoiesis of Indeterminate Potential in People with HIV: a report from the REPRIEVE Trial. in Blood Advances.

12-22-23 Congrats @artschuermans, @APournamdari & @mchonig on their latest work. Integrative proteomic analyses across common cardiac diseases yield new mechanistic insights and enhanced prediction in medRxiv.

12-12-23 Delighted to share our study by Dr. Jemma Cho, Cumulative Diastolic Blood Pressure Burden in Normal Systolic Blood Pressure and Cardiovascular Disease published in Hypertension.

12-11-23 Congratulations Dr. Aniruddh Patel for receiving an K08 NOA!

11-14-23 Drs. Tet Nakao and Pradeep Natarajan published a letter in the New England Journal of Medicine Familial Clonal Hematopoiesis in a Long Telomere Syndrome

11-14-23 Drs. Akl Fahed and Pradeep Natarajan recently published in Atherosclerosis Clinical applications of polygenic risk score for coronary artery disease through the life course. 

10-31-23 Flagship MGB Biobank paper by Dr. Satoshi Koyama is up as a preprint! Decoding Genetics, Ancestry, and Geospatial Context for Precision Health.

10-20-23 Congratulation Dr. Zhi Yu for being named a Stat Wunderkid

10-13-23 A recent collaboration with Dr. Lauren Reescamp and the Natarajan Lab led to this publication: Concordance of a High Lipoprotein(a) Concentration Among Relatives.

10-11-23 A big congratulations to Yuxuan Wang et al for the recent medRxiv preprint. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study.

9-29-23 Congratulations Dr. Sarah Urbut and the rest of the lab! Published in iScience  Bayesian multivariate genetic analysis improves translational insights.

9-15-23 Congratulations to Dr. Zhi Yu on her K99 NOA!

9-15-23 Jiwoo Lee, one of our medical students, just published in Nature Communications. Quantifying the causal impact of biological risk factors on healthcare costs.

8-28-23 Congratulations, Dr. Jemma So Mi Cho and Nina Kathiresan! Published in JAMA Cardiology. Representation of Race and Ethnicity in the Contemporary US Health Cohort All of US Research Program.

8-2-23 Dr. Zhi Yu is on fire! She published this work Genetic modification of inflammation and clonal hematopoiesis- associated cardiovascular risk in the Journal of Clinical Investigation. Her preprint Human Plasma Proteomic Profile of Clonal Hematopoiesis is also up.

7-27-23 Congrats Art Schuermans et al. for your publication in Circulation Research. Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women.

7-7-23 Amazing work Aniruddh Patel! Published in Nature Medicine A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.

6-27-23 The Natarajan folks have been busy. Art Schuermans, Sara Haidermota, and Drs Tet Nakao, Yunfeng Ruan, Satoshi Koyama, Zhi Yu, Mesbah Uddin, Whitney Hornsby, Pradeep Natarajan, and Mike Honigberg all contributed to this Nature Genetics paper Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood.

6-27-23 Jemma So Mi Cho along with a few other lab folks recently published Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study.

6-16-23 Drs. Derek Klarin, Kaavya Paruchuri, Krishna Aragam, Ida Surakka, and Pradeep Natarajan all contributed to this Nature Genetics paper Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.

5-17-23 A Nature publication published in April. Clonal haematopoiesis and risk of chronic liver disease.

4-26-23 A truly joint lab effort Genetic and Clinical Factors Underlying a Self-Reported Family History of Heart Disease.

3-17-23 Our latest publication Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.

12-9-22 Just published Clonal Hematopoiesis and Risk of Incident Lung Cancer.

11-11-22 A couple more publications to end this week. 2022 Jeffrey M. Hoeg Award Lecture: Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease and Venous Thromboembolism Polygenic Risk Score Associates With Pulmonary Hypertension in the UK Biobank.

11-08-22 This week, Drs. Tetsushi Nakao and Pradeep Natarajan published Clonal hematopoiesis, multi-comics and coronary artery disease in Nature Cardiovascular Research.

11-08-22 Circulation: Genomic and Precision Medicine just published Association of a Multi-Ancestry Genome-Wide Blood Pressure Polygenic Risk Score with Adverse Cardiovascular Events

11-04-22 Our latest publication in Blood Clonal hematopoiesis of indeterminate potential and risk of death from COVID-19

10-19-22 A new publication for the Natarajan Lab, Clonal Hematopoiesis of Indeterminate Potential and Kidney Function Decline in the General Population.

10-13-22 Just published in Nature Communications Whole genome sequence analysis of blood lipid levels in >66,000 individuals.

09-30-22 Ending off September with two publications Measured Blood Pressure, Genetically Predicted Blood Pressure, and Cardiovascular Disease Risk in the UK Biobank and Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes.

09-20-22 Considering a career as a physician-scientist? Here’s a timely publication: Launching a career as a physician-scientist.

09-20-22 Just published in Science Translational Medicine Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.

09-13-22 Congratulations Mesbah Uddin and the Natarajan Lab for their recently published paper, Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease

08-30-22 The latest paper to close out August, Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.

08-23-22 The Natarajan Lab recently published Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods and Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.

08-18-22 For the long days of summer, here is some light reading. Clinical Implementation of Combined Monogenic and Polygenic Risk Disclosure for Coronary Artery Disease.

08-10-22 Newsweek just announced that Massachusetts General Hospital has been chosen as the #1 hospital in the world for cardiology. Honored to work alongside this amazing group of colleagues!

08-10-22 Welcome to our two latest lab members. Ida Surakka an affiliated faculty member and Tajmara Antoine a clinical research coordinator.

08-08-22 For the hot days of August! A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.

08-02-22 More summer reading! Large-scale genome-wide association study of coronary artery disease in genetically diverse populations and Germline genomic and phenomic landscape of clonal hematopoiesis in 323,112 individuals.

07-21-22 A summer publication to add to your reading list! Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality

07-01-22 To start out the second half of the year, the lab published this article:  A MUC5B Gene Polymorphism, rs35705950-T Confers Protective Effects Against COVID-19 Hospitalization but not Severe Disease or Mortality

06-29-22 Two new articles published this month. TET2-mutant clonal hematopoiesis and risk of gout and the Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait.

06-16-22 Nature Genetics published the Natarajan Lab’s most recent work, Genetic analysis of right heart structure and function in 40,000 people.

06-13-22 Welcome to Shriie Ganesh. She joined our incredibly talented group of clinical research coordinators.

06-03-22 Two publications to note from the past couple of weeks. Genetic Architecture and Clinical Outcomes of the Fredrickson-Levy-Lees Dyslipoproteinemias and Sex Differences in Temporal Trends of Cardiovascular Health in Young US Adults.

05-24-22 On May 14th the American Heart Association Vascular Discovery Scientific Sessions held in Seattle awarded Dr. Pradeep Natarajan with the Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award. Congratulations Pradeep!

05-12-22 A mid-May publication. Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality.

05-05-22 Read a few of the papers published during April and May. “Genetics of smoking and risk of clonal hematopoiesis“, “Lipoprotein(a), menopausal hormone therapy, and risk of coronary heart disease in postmenopausal women“, “Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential“, and “Genetic association of body mass index with pathologic left ventricular remodeling“.

4-25-22 Our new Associate Director, Whitney Hornsby, joined the Natarajan Lab today!

03-14-22 Another week of publications for the Natarajan Lab. “Genetic and phenotypic profiling of supranormal ejection fraction reveals decreased survival and underdiagnosed heart failure” and “Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society For Preventive Cardiology Clinical Practice Statement“.

03-08-22 Congratulations Maryam Zekavat for defending her PhD and for the publication of her most recent work. “Fibrillar Collagen Variants in Spontaneous Coronary Artery Dissection“.

03-07-22 Yet more papers published “Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society for Preventive Cardiology Clinical Practice Statement.” and “Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study“.

2-28-22 The next paper out from the Natarajan Lab is “Diastolic Blood Pressure Alleles Improve Congenital Heart Defect Repair Outcomes.”

2-18-22 A slew of papers have been published over the last month in the Natarajan Lab. Here are a few of them. Michael Honigberg presented his latest research in “Microvascular Outcomes in Women With a History of Hypertension in Pregnancy“. Mark Trinder published his work titled “Repeat Measures of Lipoprotein(a) Molar Concentration and Cardiovascular Risk“. Base on her most recent studies, Leland Hull published her piece “Self-rated family health history knowledge among All of Us program participants“. Watch here for more publications!

1-13-22 More welcomes are in order as the Natarajan lab continues to grow. Welcome to Yunfeng Ruan, Buu Troung, Michael Pang, Nishant Uppal.

11-24-21 Welcome to Jacqueline Dron, Akl Fahed, and Aniruddh Patel!

11-8-21 Congratulations to the Natarajan Lab including Maryam Zekevat, Vineet Raghu, Mark Trinder, Satoshi Koyama, Mike Honigberg, Zhi Yu, Sarah Urbut, Sara Haidermota, and Pradeep Natarajan for publishing Deep Learning of the Retina Enables Phenome- and Genome-wide Analyses of the Microvasculature .

10-18-21 Despite being in her first year as a Cardiology Fellow, Dr. Sarah Urbut came in 2nd place in the Fellows Basic Science Category at the Northwestern Cardiovascular Young Investigators’ Forum. Congratulations Dr. Urbut!

9-28-21 Newsweek published their list of the world’s Best Specialized Hospitals 2022 – Cardiology. At the top, you will find the Massachusetts General Hospital Corrigan Minehan Heart Center! Congratulations to all who make this a world-class center.

 

Press

2022

July 25, 2022 Esperion Announces Establishment of Scientific Advisory Board to Support Pipeline and Life Cycle Management (Yahoo! Finance)

July 14, 2022 As Y Chromosomes Vanish With Age, Heart Risks May Grow (NYTimes)

July 13, 2022 OurHealth Explores Why South Asian Ancestry is Now Considered a Risk-Enhancing Factor for Cardiovascular Disease (India New England)

June 2, 2022 Gender gap in some heart risk factors widens among young adults. (American Heart Association News)

April 9, 2022 Higher Lp(a) Linked to Increased Risk of Incident CHD in Postmenopausal Patients (HCPLive)

March 2, 2022 New genetic insights on common cause of heart attack in younger women (Harvard Gazette)

March 2, 2022 Common cause of heart attacks in younger adults linked to gene variants (MGH News)

February 14, 2022 Damage from preeclampsia may be seen decades later in the eyes (American Heart Association News)

February 14, 2022 Depression may increase the risk of type 2 diabetes and stroke’ (Daily Mail)

January 27, 2022 TenSixteen Bio Launches with Funding from Foresite Capital and GV As the First Company to Use CHIP to Treat Age-Related Diseases (Business Wire)

2021

November 17, 2021 Chip and Stroke: Risk for Cerebrovascular Diseases Dwells in the Bone (American Stroke Association)

August 16, 2021 Study suggests link between diet and clonal hematopoiesis of indeterminate potential (CHIP) (NHLBI)

August 11th, 2021 Have a heart: It’s the only one you’ve got (The Bay State Banner)

July 1, 2021 X Chromosome locus is associated with lower atherogenic lipids, favorable cardiometabolic traits (MGH Advances in Motion)

June 10, 2021 Healthier diets can reduce the risk of clonal hematopoiesis, adverse cardiovascular outcomes (Cardiovascular Business)

June 9, 2021 Ranking the risk of heart disease (Nature)

June 9, 2021 An Unhealthy Diet Feeds Into Clonal Hematopoiesis (MedPage Today)

June 7, 2021 Chromosomal Changes in White Blood Cells May Increase Risk of Infections (National Cancer Institute, Division of Cancer Epidemiology and Genetics)

June 7, 2021 Chromosomal changes in white blood cells increase risk of severe infections (YaleNews)

June 7, 2021 Study links blood cell mutations to increased infection risk with age (Broad Institute)

May 20, 2021 The Cholesterol Deniers (proto MGH Dispatches from the Frontiers of Medicine)

May 17, 2021 New STRENGTH analysis puts spotlight on CV impact of omega-3 fatty acids (Healio)

February 10, 2021 Analysis of largest, most diverse genetic data set released (ScienceDaily)

January 22, 2021 The Take Home: AHA Scientific Sessions (Healio)

2020

November 25, 2020 BIDMC researchers reveal how genetic variations are linked to COVID-19 disease severity (EurekAlert!)

November 24, 2020 Fitbit study finds heart rate variability fluctuates by age, gender, time of day and activity level (MobiHealth News)

November 15, 2020 ‘Nocebo effect’ may explain many cases of statin intolerance: SAMSON (Cardiology Today)

November 15, 2020 STRENGTH: No CV benefit with omega-3 carboxylic acid (Cardiology Today)

November 12, 2020 Mass General Study Details How Premature Menopause Impacts Heart Health (Endocrinology Network)

November 2, 2020 Management of Blood Pressure, BMI May Reduce the Risk of Hypertensive Disorders of Pregnancy (MGH Advances in Motion)

October 30, 2020 LPA genetic risk score may be similar to Lp(a) measurements at predicting ASCVD (Cardiology Today)

October 14, 2020 Germline Variants Contribute to Risk of Developing Aging-Related Clonal Hematopoiesis (Genome Web)

October 14, 2020 Studies reveal mutations that boost blood stem cell growth and increase leukemia and heart disease risk (Broad Institute)

October 7, 2020 Lp(a) and LPA Genetic Risk Score Both Predict Incident ASCVD: UK Biobank (tctMD)

October 7, 2020 Genetic Testing for Lipoprotein(a) Comparable to Conventional Blood Work (DocWire News)

July 17, 2020 ‘Before a tsunami hits’ (The Harvard Gazette)

July 15, 2020 Physician-scientists from the Broad community talk about their experiences caring for COVID-19 patients (Broad Institute)

May 14, 2020 A Study Said Covid Wasn’t That Deadly. The Right Seized It (New York Times)

May 5, 2020 Later CVD Risk From Hypertension in Pregnancy Vastly Underestimated (tctMD)

April 14, 2020 Four Dispatches from the Pandemic’s Front Lines (Wall Street Journal)

March 20, 2020 For physicians and nurses on the front line, there’s worry over bringing coronavirus home (Boston Globe)

February 18, 2020 Studies Uncover Cardiovascular Disease Risk Factors in Women (MGH Advances in Motion)

February 4, 2020 Cardiovascular Risk After Hypertensive Disorder of Pregnancy Persists into Midlife (MGH Advances in Motion)

2019

November 25, 2019 Gaps remain in preventative care of patients with nonobstructive CAD discovered in ED visits (MGH Advances in Motion)

November 21, 2019 Early Menopause Increases Heart Risks (New York Times)

November 20, 2019 Review: Analyzing the Latest Data on Recurrent CVD Prevention (MGH Advances in Motion)

November 12, 2019 Curbing inflammation could reduce heart disease risk linked to blood disorder (Broad Institute)

November 1, 2019 New genomic regions linked to common vascular disorder (Broad Institute)

September 18, 2019 HDL apolipoproteins may identify risk, prognosis of CAD (MGH Advances in Motion)

July 22, 2019 Nonobstructive CAD on Cardiac CTA a Golden Opportunity to Boost Statin Prescribing (tctMD)

June 14, 2019 Statin and Non Statin Drugs (AHA Check.Change.Control.Cholesterol [podcast])

June 14, 2019 Coronary Calcification (CAC score) (AHA Check.Change.Control.Cholesterol [podcast])

May 9, 2019 New Guideline Changes (AHA Check.Change.Control.Cholesterol [podcast])

2018

November 23, 2018 New Cholesterol Treatment Guidelines: A Mass General Perspective (MGH Advances in Motion)

November 20, 2018 ‘The Patient Has the Power’ in New AHA/ACC Cholesterol Guideline (Medscape)

November 11, 2018 AHA.18: Nonstatin therapies, CAC testing claim larger role in cholesterol guidelines (Cardiovascular Business)

November 10, 2018 REDUCE-IT: Prescription Fish Oil Prevents CV Events in Patients With High Triglycerides (tctMD)

October 11, 2018 Genomic risk score predicts CAD better than conventional factors (Healio, Cardiology Today)

May 29, 2018 Vitamins and mineral supplements don’t improve heart health, study says (USA Today)

February 8, 2018 Gene Knockout Testing Evidences APOC3 as a Target for Therapeutics (MGH Advances in Motion)

January 3, 2018 ‘Human Knockout Project’ in a Pakistani Population with High Levels of Consanguinity (MGH Advances in Motion)

2017

December 21, 2017 Heart disease and stroke deaths decline slightly, new statistics find (American Heart Association News)

August 15, 2017 The genetics of heart disease: An update (Harvard Heart Letter)

July 31, 2017 Patients Take Big Risks When Stopping Statins (Wall Street Journal)

July 17, 2017 Let’s Take a Moment to Discuss Cardiovascular Disease (CosmicNovo)

May 3, 2017 Amgen Offers Cholesterol Drug With First Refund Guarantee For Heart Attack Or Stroke Sufferers (WBUR / National Public Radio)

May 2, 2017 Who Needs a Statin? DNA Beats Current Risk Calculators (Medscape)

March 6, 2017 Gene Test Could Predict Subclinical CHD Risk, Statin Benefit (Medscape)

2016

November 9, 2016 Will unanticipated genetic mutations lead to subsequent disease? (Medical Xpress)

October 28, 2016 These pricey cholesterol drugs aren’t selling. And that has the biotech industry sweating (STAT News)

April 14, 2016 High cholesterol: Common and silent (Bay State Banner)

April 1, 2016 The Surprising Connection Between Bronchitis And Heart Attacks (Self)

January 15, 2016 Heart disease: All in the family history (Harvard Men’s Health Watch)

2015

October 6, 2015 Statin use to reduce cardiovascular risk (MGH News)

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