5-28-25 Another publication for the lab, Dr. Alyssa Monica Flores takes the lead on Polygenic Prediction of Peripheral Artery Disease and Major Adverse Limb Events. JAMA Cardiology

5-28-25 Congratulations Christopher Robinson for your publication Bench to all Bedsides in Genomics and Precision Medicine  in the Journal of the American Heart Association.

5-28-25 Dr. Sarah Urbut has been awarded the prestigious Burroughs Wellcome Fund Career Award for Medical Scientists. Congratulations, Sarah!!

5-8-25 Congratulations are in order for a few folks from the lab. First, Francesca Kim for winning the Top Genetics Poster at ARVO (Assoc for Research in Vision and Ophthalmology) for trainees! Second, Dr. Zhi Yu for winning her 2nd Tiger Award an Early Career Achievement from the CHARGE consortium. Third, Shriie Ganesh for winning a 2025 AHA summer student scholarship to return to the lab this summer. She received the top score and, consequently, she is named the Howard S. Silverman Scholar.

4-30-25 Congrats Adyant Shankar, Buu Truong, and Drs. Satoshi Koyama, Kaavya Paruchuri, Aniruddh Patel, and Whitney Hornsby on your publication in JACC Adv Genotype-Phenotype Low-Density Lipoprotein Cholesterol Discordance and Coronary Artery Disease Risk

4-24-25 Congratulations Buu Truong, Himani Kamineni, and Drs. Whitney Hornsby and Satoshi Koyama for their recent publication in medRxiv Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global Biobank!

4-17-25 Congratulations Dr. Zhi Yu for your publication in Journal of the American Society of Nephrology Deciphering Clonal Hematopoiesis of Indeterminate Potential: Methods, Mechanisms, and Implications for Kidney Diseases!

3-26-25 Congrats to Dr. Leland Hull for publishing Direct-to-Consumer Genetic Testing for Cardiovascular Disease: A Scientific Statement From the American Heart Association  in Circulation!

2-13-25 A flurry of publications from the Natarajan Lab! In Nature Communications, lead author Anika Misra published Instability of high polygenic risk classification and mitigation by integrative scoring. In Hypertension, lead author Dr. So Mi Jemma Cho published East and South Asian-Specific Blood Pressure Trajectories and Cardiovascular Disease. In JACC Advances, lead author Dr. Aeron Small published Longitudinal Evaluation of Genetic Hypertrophic Cardiomyopathy Penetrance and Transition to Disease in an Academic Biobank. Congratulations all!

2-13-25 Welcome to our latest lab members! Sydney Corey, a HMS student, Victoria Gonzales Macuare, a CRC, Dr. Neil Zheng, a BWH resident, and Dr. Daniel Weiner, a MGH resident.

1-28-25 Congrats again to Dr. Sarah Urbut for her publication Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course in Circ Genom Precis Med.

1-23-25 Congrats to Dr. Sarah Urbut, as of 8-1 she will be an MGH cardiologist!

1-13-25 Journal of Cardiac Failure just published Dr. Kaavya Paruchuri’s paper Implementation of a digital disease management platform for heart failure: AMAZE Congratulations, Kaavya!

11-30-24 Congratulations Drs. Jacqueline Dron, Gina Peloso, and Pradeep Natarajan for their recent publication in Current Opinion in Lipidology The breadth and impact of the Global Lipids Genetics Consortium.

11-21-24 Just in! Nature Cardiovascular Research has just published the work of Art Schuermans, and many from the lab. Integrative proteomic analyses across common cardiac diseases yield mechanistic insights and enhanced prediction.

11-4-24 Congratulations Drs. Tetsushi Nakao and Satoshi Koyama for their work on Genomic, phonemic, and geographic associations of leukocyte telomere length in the United States.

10-4-24 Congrats Drs Alyssa Flores and Aniruddh Patel for their preprint An integrated polygenic score stratifies risk of peripheral artery disease and adverse limb events in ancestrally diverse cohorts

10-2-24 Congrats Dr. So Mi Cho and the Natarajan lab for their publication in JACC Advances Improving Cardiovascular Disease Primary Prevention Treatment Thresholds in a New England Health Care System.

9-18-24 Congratulations to Dr. Satoshi Koyama for being awarded the Gill Heart and Vascular Institute Early Contributions to Cardiovascular Research Award

9-9-24 Just in, Nature Communications published Dr. Mesbah Uddin’s paper Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis.

8-27-24 Congratulations Dr. Zhi Yu for her publication in Nat Rev Genet Genetic variation across and within individuals.

8-27-24 Congratulations Jiwoo Lee for their publication in Arteriosclerosis, Thrombosis, and Vascular Biology Integrative metabolomics differentiate coronary artery disease, peripheral artery disease, and venous thromboembolism risks. 

7-24-24 Congratulations Anika Misra and many other lab members, for their preprint
Instability of high polygenic risk classification and mitigation by integrative scoring!

7-17-24 We are thrilled to announce Dr. Kaavya Paruchuri’s new role at MGH. She is now the Clinical Operations Director for Cardiovascular Medicine!

7-4-24 Congratulations to Dr. Tiffany Bellomo for her publication in Journal of Lipid Research. Associations between lipoprotein (a), oxidized phospholipids, and extra-coronary vascular disease.

6-28-24 Congratulations to Dr. Whitney Hornsby for receiving the MGH Dept of Medicine Equity Award for her work on the OurHealth Project.

6-18-24 Congratulations to Dr. Kaavya Paruchuri for her publication in J Am Heart Assoc. Using Sex-Specific Polygenic Risk to Prognosticate Coronary Artery Disease in Women.

6-13-24 Congratulations to Dr. Pradeep Natarajan for being presented with the Harvard Medical School Young Mentor Award!

6-12-24 Congrats to Dr. Alyssa Monica Flores (and her co-mentor Dr. Aniruddh Patel) for receiving the LaDue fellowship from Harvard Medical School!

6-7-24 Congratulations to Dr. Sarah Urbut for her publication in Nature Communications MSGene: a multistate model using genetic risk and the electronic health record applied to lifetime risk of coronary artery disease.

6-7-24 Congratulations to Dr. Tiffany Bellomo – again! NHLBI has funded her F32 application to study the “Genetics of carotid artery disease progression…”

6-6-24 Congrats Dr. Kaavya Paruchuri for receiving the 2024 MGH Eleanor & Miles Shore Faculty Development Award!

6-3-24 Congratulations Drs. Thomas Gilliland and Jacqueline Dron on your Circ Res publication Genetic Architecture and Clinical Outcomes of Combined Lipid Disturbances.

5-29-24 Congratulations Dr. Pradeep Natarajan on your NEJM publication Exceptional Genetics, Generalizable Therapeutics, and Coronary Artery Disease.

5-10-24 Congratulations Buu Truong and the Natarajan Lab on your Med publication Modification of coronary artery disease clinical risk factors by coronary artery disease polygenic risk score

4-30-24 Congratulations Drs. Tiffany Bellomo and Pradeep Natarajan on your new study in JACC Journals Clonal Hematopoiesis Among Patients with Asymptomatic Carotid Stenosis Compounds Risk of Cardiovascular Death.

4-2-24 Dr. Roger Zou led a group of Natarajan Lab scientists in publishing this article. Polygenic Scores and Preclinical Cardiovascular Disease in Individuals with HIV: Insights From the REPRIEVE Trial Congratulations!

4-2-24 Congrats Drs. Zhi Yu and Mesbah Uddin on your Nature Review Genetics publication! Genetic variation across and within individuals

2-15-24 Congrats Dr. Aeron Small on your recent publication in JAMA Cardiology. Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations.

1-17-24 Welcome 2024! Congrats Dr. Romit Bhattacharya! Risk Factors for Clonal Hematopoiesis of Indeterminate Potential in People with HIV: a report from the REPRIEVE Trial. in Blood Advances.

12-22-23 Congrats @artschuermans, @APournamdari & @mchonig on their latest work. Integrative proteomic analyses across common cardiac diseases yield new mechanistic insights and enhanced prediction in medRxiv.

12-12-23 Delighted to share our study by Dr. Jemma Cho, Cumulative Diastolic Blood Pressure Burden in Normal Systolic Blood Pressure and Cardiovascular Disease published in Hypertension.

12-11-23 Congratulations Dr. Aniruddh Patel for receiving an K08 NOA!

11-14-23 Drs. Tet Nakao and Pradeep Natarajan published a letter in the New England Journal of Medicine Familial Clonal Hematopoiesis in a Long Telomere Syndrome

11-14-23 Drs. Akl Fahed and Pradeep Natarajan recently published in Atherosclerosis Clinical applications of polygenic risk score for coronary artery disease through the life course. 

10-31-23 Flagship MGB Biobank paper by Dr. Satoshi Koyama is up as a preprint! Decoding Genetics, Ancestry, and Geospatial Context for Precision Health.

10-20-23 Congratulation Dr. Zhi Yu for being named a Stat Wunderkid

10-13-23 A recent collaboration with Dr. Lauren Reescamp and the Natarajan Lab led to this publication: Concordance of a High Lipoprotein(a) Concentration Among Relatives.

10-11-23 A big congratulations to Yuxuan Wang et al for the recent medRxiv preprint. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study.

9-29-23 Congratulations Dr. Sarah Urbut and the rest of the lab! Published in iScience  Bayesian multivariate genetic analysis improves translational insights.

9-15-23 Congratulations to Dr. Zhi Yu on her K99 NOA!

9-15-23 Jiwoo Lee, one of our medical students, just published in Nature Communications. Quantifying the causal impact of biological risk factors on healthcare costs.

8-28-23 Congratulations, Dr. Jemma So Mi Cho and Nina Kathiresan! Published in JAMA Cardiology. Representation of Race and Ethnicity in the Contemporary US Health Cohort All of US Research Program.

8-2-23 Dr. Zhi Yu is on fire! She published this work Genetic modification of inflammation and clonal hematopoiesis- associated cardiovascular risk in the Journal of Clinical Investigation. Her preprint Human Plasma Proteomic Profile of Clonal Hematopoiesis is also up.

7-27-23 Congrats Art Schuermans et al. for your publication in Circulation Research. Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women.

7-7-23 Amazing work Aniruddh Patel! Published in Nature Medicine A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.

6-27-23 The Natarajan folks have been busy. Art Schuermans, Sara Haidermota, and Drs Tet Nakao, Yunfeng Ruan, Satoshi Koyama, Zhi Yu, Mesbah Uddin, Whitney Hornsby, Pradeep Natarajan, and Mike Honigberg all contributed to this Nature Genetics paper Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood.

6-27-23 Jemma So Mi Cho along with a few other lab folks recently published Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study.

6-16-23 Drs. Derek Klarin, Kaavya Paruchuri, Krishna Aragam, Ida Surakka, and Pradeep Natarajan all contributed to this Nature Genetics paper Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.

5-17-23 A Nature publication published in April. Clonal haematopoiesis and risk of chronic liver disease.

4-26-23 A truly joint lab effort Genetic and Clinical Factors Underlying a Self-Reported Family History of Heart Disease.

3-17-23 Our latest publication Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.

12-9-22 Just published Clonal Hematopoiesis and Risk of Incident Lung Cancer.

11-11-22 A couple more publications to end this week. 2022 Jeffrey M. Hoeg Award Lecture: Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease and Venous Thromboembolism Polygenic Risk Score Associates With Pulmonary Hypertension in the UK Biobank.

11-08-22 This week, Drs. Tetsushi Nakao and Pradeep Natarajan published Clonal hematopoiesis, multi-comics and coronary artery disease in Nature Cardiovascular Research.

11-08-22 Circulation: Genomic and Precision Medicine just published Association of a Multi-Ancestry Genome-Wide Blood Pressure Polygenic Risk Score with Adverse Cardiovascular Events

11-04-22 Our latest publication in Blood Clonal hematopoiesis of indeterminate potential and risk of death from COVID-19

10-19-22 A new publication for the Natarajan Lab, Clonal Hematopoiesis of Indeterminate Potential and Kidney Function Decline in the General Population.

10-13-22 Just published in Nature Communications Whole genome sequence analysis of blood lipid levels in >66,000 individuals.

09-30-22 Ending off September with two publications Measured Blood Pressure, Genetically Predicted Blood Pressure, and Cardiovascular Disease Risk in the UK Biobank and Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes.

09-20-22 Considering a career as a physician-scientist? Here’s a timely publication: Launching a career as a physician-scientist.

09-20-22 Just published in Science Translational Medicine Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.

09-13-22 Congratulations Mesbah Uddin and the Natarajan Lab for their recently published paper, Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease

08-30-22 The latest paper to close out August, Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.

08-23-22 The Natarajan Lab recently published Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods and Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.

08-18-22 For the long days of summer, here is some light reading. Clinical Implementation of Combined Monogenic and Polygenic Risk Disclosure for Coronary Artery Disease.

08-10-22 Newsweek just announced that Massachusetts General Hospital has been chosen as the #1 hospital in the world for cardiology. Honored to work alongside this amazing group of colleagues!

08-10-22 Welcome to our two latest lab members. Ida Surakka an affiliated faculty member and Tajmara Antoine a clinical research coordinator.

08-08-22 For the hot days of August! A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.

08-02-22 More summer reading! Large-scale genome-wide association study of coronary artery disease in genetically diverse populations and Germline genomic and phenomic landscape of clonal hematopoiesis in 323,112 individuals.

07-21-22 A summer publication to add to your reading list! Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality

07-01-22 To start out the second half of the year, the lab published this article:  A MUC5B Gene Polymorphism, rs35705950-T Confers Protective Effects Against COVID-19 Hospitalization but not Severe Disease or Mortality

06-29-22 Two new articles published this month. TET2-mutant clonal hematopoiesis and risk of gout and the Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait.

06-16-22 Nature Genetics published the Natarajan Lab’s most recent work, Genetic analysis of right heart structure and function in 40,000 people.

06-13-22 Welcome to Shriie Ganesh. She joined our incredibly talented group of clinical research coordinators.

06-03-22 Two publications to note from the past couple of weeks. Genetic Architecture and Clinical Outcomes of the Fredrickson-Levy-Lees Dyslipoproteinemias and Sex Differences in Temporal Trends of Cardiovascular Health in Young US Adults.

05-24-22 On May 14th the American Heart Association Vascular Discovery Scientific Sessions held in Seattle awarded Dr. Pradeep Natarajan with the Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award. Congratulations Pradeep!

05-12-22 A mid-May publication. Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality.

05-05-22 Read a few of the papers published during April and May. “Genetics of smoking and risk of clonal hematopoiesis“, “Lipoprotein(a), menopausal hormone therapy, and risk of coronary heart disease in postmenopausal women“, “Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential“, and “Genetic association of body mass index with pathologic left ventricular remodeling“.

4-25-22 Our new Associate Director, Whitney Hornsby, joined the Natarajan Lab today!

03-14-22 Another week of publications for the Natarajan Lab. “Genetic and phenotypic profiling of supranormal ejection fraction reveals decreased survival and underdiagnosed heart failure” and “Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society For Preventive Cardiology Clinical Practice Statement“.

03-08-22 Congratulations Maryam Zekavat for defending her PhD and for the publication of her most recent work. “Fibrillar Collagen Variants in Spontaneous Coronary Artery Dissection“.

03-07-22 Yet more papers published “Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society for Preventive Cardiology Clinical Practice Statement.” and “Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study“.

2-28-22 The next paper out from the Natarajan Lab is “Diastolic Blood Pressure Alleles Improve Congenital Heart Defect Repair Outcomes.”

2-18-22 A slew of papers have been published over the last month in the Natarajan Lab. Here are a few of them. Michael Honigberg presented his latest research in “Microvascular Outcomes in Women With a History of Hypertension in Pregnancy“. Mark Trinder published his work titled “Repeat Measures of Lipoprotein(a) Molar Concentration and Cardiovascular Risk“. Base on her most recent studies, Leland Hull published her piece “Self-rated family health history knowledge among All of Us program participants“. Watch here for more publications!

1-13-22 More welcomes are in order as the Natarajan lab continues to grow. Welcome to Yunfeng Ruan, Buu Troung, Michael Pang, Nishant Uppal.

11-24-21 Welcome to Jacqueline Dron, Akl Fahed, and Aniruddh Patel!

11-8-21 Congratulations to the Natarajan Lab including Maryam Zekevat, Vineet Raghu, Mark Trinder, Satoshi Koyama, Mike Honigberg, Zhi Yu, Sarah Urbut, Sara Haidermota, and Pradeep Natarajan for publishing Deep Learning of the Retina Enables Phenome- and Genome-wide Analyses of the Microvasculature .

10-18-21 Despite being in her first year as a Cardiology Fellow, Dr. Sarah Urbut came in 2nd place in the Fellows Basic Science Category at the Northwestern Cardiovascular Young Investigators’ Forum. Congratulations Dr. Urbut!

9-28-21 Newsweek published their list of the world’s Best Specialized Hospitals 2022 – Cardiology. At the top, you will find the Massachusetts General Hospital Corrigan Minehan Heart Center! Congratulations to all who make this a world-class center.