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Clinical Training

[updated 02/26/2021]

Here are a select set of high yield resources to review during the Massachusetts General Hospital Cardiology Fellowship and Medicine Residency rotation in Prevention & Genetics. feedback

Review / Statement / Guideline / Editorial Papers

Preventive Cardiology

Cardiovascular Genetics

Aortopathy Genetics

Arrhythmia Genetics

Atherosclerosis Genetics

Women’s Heart Health

Online Calculators

Preventive Cardiology

Atherosclerosis Genetics

 

 Review / Statement / Guideline / Editorial Papers 

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2018 ACC/AHA Guideline on the Management of Blood Cholesterol

2019 ACC/AHA Primary Prevention Guidelines

2019 ESC/EAS Guidelines for the Management of Dyslipidemias: Lipid Modification to Reduce Cardiovascular Risk

2020 American Diabetes Association Standards of Medical Care in Diabetes: Cardiovascular Disease and Risk Management

2020 ACC Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Pathways with Type 2 Diabetes and ASCVD

Practical Guide to Prescribing SGLT2 Inhibitors

Practical Guide to Prescribing GLP-1 Receptor Agonists

Inflammation, C-Reactive Protein, and Cardiovascular Disease.

Dalal HM, Doherty P, Taylor RS. Cardiac rehabilitation. BMJ. 2015 Sep 29;351:h5000. doi: 10.1136/bmj.h5000. Review. PubMed PMID: 26419744; PubMed Central PMCID: PMC4586722.

Tsimikas S. A Test in Context: Lipoprotein(a): Diagnosis, Prognosis, Controversies, and Emerging Therapies. J Am Coll Cardiol. 2017 Feb 14;69(6):692-711. doi: 10.1016/j.jacc.2016.11.042. PMID: 28183512.

Nabel EG, Braunwald E. A tale of coronary artery disease and myocardial infarction. N Engl J Med. 2012 Jan 5;366(1):54-63. doi: 10.1056/NEJMra1112570. Erratum in: N Engl J Med. 2012 Mar 8;366(10):970. PubMed PMID: 22216842.

Grayburn PA. Interpreting the coronary-artery calcium score. N Engl J Med. 2012 Jan 26;366(4):294-6. doi: 10.1056/NEJMp1110647. PubMed PMID: 22276819.

Ridker PM. Inflammation, C-reactive protein, and cardiovascular disease: moving past the marker versus mediator debate. Circ Res. 2014 Feb 14;114(4):594-5. doi: 10.1161/CIRCRESAHA.114.303215. PubMed PMID: 24526672.

Witztum JL, Ginsberg HN. Lipoprotein (a): Coming of Age at Last. J Lipid Res. 2016 Mar;57(3):336-9. doi: 10.1194/jlr.E066985. Epub 2016 Feb 2. Review. PubMed PMID: 26839334; PubMed Central PMCID: PMC4766984.

Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, de Ferranti SD, Floyd J, Fornage M, Gillespie C, Isasi CR, Jiménez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Mackey RH, Matsushita K, Mozaffarian D, Mussolino ME, Nasir K, Neumar RW, Palaniappan L, Pandey DK, Thiagarajan RR, Reeves MJ, Ritchey M, Rodriguez CJ, Roth GA, Rosamond WD, Sasson C, Towfighi A, Tsao CW, Turner MB, Virani SS, Voeks JH, Willey JZ, Wilkins JT, Wu JH, Alger HM, Wong SS, Muntner P; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation. 2017 Mar 7;135(10):e146-e603. doi: 10.1161/CIR.0000000000000485. Epub 2017 Jan 25. Review. Erratum in: Circulation. 2017 Mar 7;135(10 ):e646. Circulation. 2017 Sep 5;136(10):e196. PubMed PMID: 28122885; PubMed Central PMCID: PMC5408160.

Collins R, Reith C, Emberson J, Armitage J, Baigent C, Blackwell L, Blumenthal R, Danesh J, Smith GD, DeMets D, Evans S, Law M, MacMahon S, Martin S, Neal B, Poulter N, Preiss D, Ridker P, Roberts I, Rodgers A, Sandercock P, Schulz K, Sever P, Simes J, Smeeth L, Wald N, Yusuf S, Peto R. Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet. 2016 Nov 19;388(10059):2532-2561. doi: 10.1016/S0140-6736(16)31357-5. Epub 2016 Sep 8. Review. Erratum in: Lancet. 2017 Feb 11;389(10069):602. PubMed PMID: 27616593.

 

Cirino AL, Harris S, Lakdawala NK, Michels M, Olivotto I, Day SM, Abrams DJ, Charron P, Caleshu C, Semsarian C, Ingles J, Rakowski H, Judge DP, Ho CY. Role of Genetic Testing in Inherited Cardiovascular Disease: A Review. JAMA Cardiol. 2017 Oct 1;2(10):1153-1160. doi: 10.1001/jamacardio.2017.2352. PubMed PMID: 28793145.

 

Aortopathy Genetics top

Coming soon

 

Arrhythmia Genetics top

2011 HRS/EHRA Channelopathy / Cardiomyopathy genetic testing Expert Consensus Statement

 

Atherosclerosis Genetics top

2015 AHA Familial Hypercholesterolemia Scientific Statement

Scheuner MT. Genetic evaluation for coronary artery disease. Genet Med. 2003 Jul-Aug;5(4):269-85. Review. PubMed PMID: 12865756.

Hovingh GK, Davidson MH, Kastelein JJ, O’Connor AM. Diagnosis and treatment of familial hypercholesterolaemia. Eur Heart J. 2013 Apr;34(13):962-71. doi: 10.1093/eurheartj/eht015. Epub 2013 Feb 14. Review. PubMed PMID: 23416791.

Stitziel NO, MacRae CA. A clinical approach to inherited premature coronary artery disease. Circ Cardiovasc Genet. 2014 Aug;7(4):558-64. doi: 10.1161/CIRCGENETICS.113.000152. PubMed PMID: 25140063; PubMed Central PMCID: PMC4403638.

Sturm AC, Knowles JW, Gidding SS, Ahmad ZS, Ahmed CD, Ballantyne CM, Baum SJ, Bourbon M, Carrié A, Cuchel M, de Ferranti SD, Defesche JC, Freiberger T, Hershberger RE, Hovingh GK, Karayan L, Kastelein JJP, Kindt I, Lane SR, Leigh SE, Linton MF, Mata P, Neal WA, Nordestgaard BG, Santos RD, Harada-Shiba M, Sijbrands EJ, Stitziel NO, Yamashita S, Wilemon KA, Ledbetter DH, Rader DJ; Convened by the Familial Hypercholesterolemia Foundation. Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel. J Am Coll Cardiol. 2018 Aug 7;72(6):662-680. doi: 10.1016/j.jacc.2018.05.044. Review. PubMed PMID: 30071997.

 

Cardiomyopathy Genetics top

2009 HFSA Cardiomyopathy genetic testing Practice Guidelines

2011 HRS/EHRA Channelopathy / Cardiomyopathy genetic testing Expert Consensus Statement

2011 ACCF/AHA Hypertrophic Cardiomyopathy Guidelines

2014 ESC Hypertrophic Cardiomyopathy Guidelines

 

Women’s Heart Health top

2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy

EUGenMed Cardiovascular Clinical Study Group, Regitz-Zagrosek V, Oertelt-Prigione S, Prescott E, Franconi F, Gerdts E, Foryst-Ludwig A, Maas AH, Kautzky-Willer A, Knappe-Wegner D, Kintscher U, Ladwig KH, Schenck-Gustafsson K, Stangl V. Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes. Eur Heart J. 2016 Jan 1;37(1):24-34. doi: 10.1093/eurheartj/ehv598. Epub 2015 Nov 3. PMID: 26530104.

Lundberg G, Wu P, Wenger N. Menopausal Hormone Therapy: a Comprehensive Review. Curr Atheroscler Rep. 2020 Jun 18;22(8):33. doi: 10.1007/s11883-020-00854-8. PMID: 32556827.

Sliwa K, van der Meer P, Petrie MC, Frogoudaki A, Johnson MR, Hilfiker-Kleiner D, Hamdan R, Jackson AM, Ibrahim B, Mbakwem A, Tschöpe C, Regitz-Zagrosek V, Omerovic E, Roos-Hesselink J, Gatzoulis M, Tutarel O, Price S, Heymans S, Coats AJ, Müller C, Chioncel O, Thum T, Thum T, de Boer RA, Jankowska E, Ponikowski P, Lyon AR, Rosano G, Seferovic PM, Bauersachs J. Risk stratification and management of women with cardiomyopathy/heart failure planning pregnancy or presenting during/after pregnancy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on Peripartum Cardiomyopathy. Eur J Heart Fail. 2021 Feb 20. doi: 10.1002/ejhf.2133. Epub ahead of print. PMID: 33609068.

 

 Online calculators 

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Preventive Cardiology 

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ACC/AHA ASCVD Risk Estimator +: 10-year ASCVD risk estimation

ACC/AHA Pooled Cohort Equations: 10-year ASCVD risk estimation

Reynold’s Risk Score: 10-year ASCVD risk estimation for non-diabetics (includes family history and hsCRP)

MESA CAC Calculator: 10-year CAD risk estimation (includes CAC)

MESA CAC Reference Values: Expected CAC score given age, sex, and ethnicity.

 

Atherosclerosis Genetics 

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Dutch Lipid Clinic Network criteria: FH clinical diagnostic criteria

Simone Broome criteria: FH clinical diagnostic criteria

MEDPED criteria: FH clinical diagnostic criteria

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