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4-2-24 Dr. Roger Zou led a group of Natarajan Lab scientists in publishing this article. Polygenic Scores and Preclinical Cardiovascular Disease in Individuals with HIV: Insights From the REPRIEVE Trial Congratulations!

4-2-24 Congrats Drs. Zhi Yu and Mesbah Uddin on your Nature Review Genetics publication! Genetic variation across and within individuals

2-15-24 Congrats Dr. Aeron Small on your recent publication in JAMA Cardiology. Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations.

1-17-24 Welcome 2024! Congrats Dr. Romit Bhattacharya! Risk Factors for Clonal Hematopoiesis of Indeterminate Potential in People with HIV: a report from the REPRIEVE Trial. in Blood Advances.

12-22-23 Congrats @artschuermans, @APournamdari & @mchonig on their latest work. Integrative proteomic analyses across common cardiac diseases yield new mechanistic insights and enhanced prediction in medRxiv.

12-12-23 Delighted to share our study by Dr. Jemma Cho, Cumulative Diastolic Blood Pressure Burden in Normal Systolic Blood Pressure and Cardiovascular Disease published in Hypertension.

12-11-23 Congratulations Dr. Aniruddh Patel for receiving an K08 NOA!

11-14-23 Drs. Tet Nakao and Pradeep Natarajan published a letter in the New England Journal of Medicine Familial Clonal Hematopoiesis in a Long Telomere Syndrome

11-14-23 Drs. Akl Fahed and Pradeep Natarajan recently published in Atherosclerosis Clinical applications of polygenic risk score for coronary artery disease through the life course. 

10-31-23 Flagship MGB Biobank paper by Dr. Satoshi Koyama is up as a preprint! Decoding Genetics, Ancestry, and Geospatial Context for Precision Health.

10-20-23 Congratulation Dr. Zhi Yu for being named a Stat Wunderkid

10-13-23 A recent collaboration with Dr. Lauren Reescamp and the Natarajan Lab led to this publication: Concordance of a High Lipoprotein(a) Concentration Among Relatives.

10-11-23 A big congratulations to Yuxuan Wang et al for the recent medRxiv preprint. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study.

9-29-23 Congratulations Dr. Sarah Urbut and the rest of the lab! Published in iScience  Bayesian multivariate genetic analysis improves translational insights.

9-15-23 Congratulations to Dr. Zhi Yu on her K99 NOA!

9-15-23 Jiwoo Lee, one of our medical students, just published in Nature Communications. Quantifying the causal impact of biological risk factors on healthcare costs.

8-28-23 Congratulations, Dr. Jemma So Mi Cho and Nina Kathiresan! Published in JAMA Cardiology. Representation of Race and Ethnicity in the Contemporary US Health Cohort All of US Research Program.

8-2-23 Dr. Zhi Yu is on fire! She published this work Genetic modification of inflammation and clonal hematopoiesis- associated cardiovascular risk in the Journal of Clinical Investigation. Her preprint Human Plasma Proteomic Profile of Clonal Hematopoiesis is also up.

7-27-23 Congrats Art Schuermans et al. for your publication in Circulation Research. Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women.

7-7-23 Amazing work Aniruddh Patel! Published in Nature Medicine A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.

6-27-23 The Natarajan folks have been busy. Art Schuermans, Sara Haidermota, and Drs Tet Nakao, Yunfeng Ruan, Satoshi Koyama, Zhi Yu, Mesbah Uddin, Whitney Hornsby, Pradeep Natarajan, and Mike Honigberg all contributed to this Nature Genetics paper Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood.

6-27-23 Jemma So Mi Cho along with a few other lab folks recently published Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study.

6-16-23 Drs. Derek Klarin, Kaavya Paruchuri, Krishna Aragam, Ida Surakka, and Pradeep Natarajan all contributed to this Nature Genetics paper Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.

5-17-23 A Nature publication published in April. Clonal haematopoiesis and risk of chronic liver disease.

4-26-23 A truly joint lab effort Genetic and Clinical Factors Underlying a Self-Reported Family History of Heart Disease.

3-17-23 Our latest publication Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.

12-9-22 Just published Clonal Hematopoiesis and Risk of Incident Lung Cancer.

11-11-22 A couple more publications to end this week. 2022 Jeffrey M. Hoeg Award Lecture: Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease and Venous Thromboembolism Polygenic Risk Score Associates With Pulmonary Hypertension in the UK Biobank.

11-08-22 This week, Drs. Tetsushi Nakao and Pradeep Natarajan published Clonal hematopoiesis, multi-comics and coronary artery disease in Nature Cardiovascular Research.

11-08-22 Circulation: Genomic and Precision Medicine just published Association of a Multi-Ancestry Genome-Wide Blood Pressure Polygenic Risk Score with Adverse Cardiovascular Events

11-04-22 Our latest publication in Blood Clonal hematopoiesis of indeterminate potential and risk of death from COVID-19

10-19-22 A new publication for the Natarajan Lab, Clonal Hematopoiesis of Indeterminate Potential and Kidney Function Decline in the General Population.

10-13-22 Just published in Nature Communications Whole genome sequence analysis of blood lipid levels in >66,000 individuals.

09-30-22 Ending off September with two publications Measured Blood Pressure, Genetically Predicted Blood Pressure, and Cardiovascular Disease Risk in the UK Biobank and Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes.

09-20-22 Considering a career as a physician-scientist? Here’s a timely publication: Launching a career as a physician-scientist.

09-20-22 Just published in Science Translational Medicine Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.

09-13-22 Congratulations Mesbah Uddin and the Natarajan Lab for their recently published paper, Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease

08-30-22 The latest paper to close out August, Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.

08-23-22 The Natarajan Lab recently published Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods and Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.

08-18-22 For the long days of summer, here is some light reading. Clinical Implementation of Combined Monogenic and Polygenic Risk Disclosure for Coronary Artery Disease.

08-10-22 Newsweek just announced that Massachusetts General Hospital has been chosen as the #1 hospital in the world for cardiology. Honored to work alongside this amazing group of colleagues!

08-10-22 Welcome to our two latest lab members. Ida Surakka an affiliated faculty member and Tajmara Antoine a clinical research coordinator.

08-08-22 For the hot days of August! A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.

08-02-22 More summer reading! Large-scale genome-wide association study of coronary artery disease in genetically diverse populations and Germline genomic and phenomic landscape of clonal hematopoiesis in 323,112 individuals.

07-21-22 A summer publication to add to your reading list! Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality

07-01-22 To start out the second half of the year, the lab published this article:  A MUC5B Gene Polymorphism, rs35705950-T Confers Protective Effects Against COVID-19 Hospitalization but not Severe Disease or Mortality

06-29-22 Two new articles published this month. TET2-mutant clonal hematopoiesis and risk of gout and the Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait.

06-16-22 Nature Genetics published the Natarajan Lab’s most recent work, Genetic analysis of right heart structure and function in 40,000 people.

06-13-22 Welcome to Shriie Ganesh. She joined our incredibly talented group of clinical research coordinators.

06-03-22 Two publications to note from the past couple of weeks. Genetic Architecture and Clinical Outcomes of the Fredrickson-Levy-Lees Dyslipoproteinemias and Sex Differences in Temporal Trends of Cardiovascular Health in Young US Adults.

05-24-22 On May 14th the American Heart Association Vascular Discovery Scientific Sessions held in Seattle awarded Dr. Pradeep Natarajan with the Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award. Congratulations Pradeep!

05-12-22 A mid-May publication. Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality.

05-05-22 Read a few of the papers published during April and May. “Genetics of smoking and risk of clonal hematopoiesis“, “Lipoprotein(a), menopausal hormone therapy, and risk of coronary heart disease in postmenopausal women“, “Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential“, and “Genetic association of body mass index with pathologic left ventricular remodeling“.

4-25-22 Our new Associate Director, Whitney Hornsby, joined the Natarajan Lab today!

03-14-22 Another week of publications for the Natarajan Lab. “Genetic and phenotypic profiling of supranormal ejection fraction reveals decreased survival and underdiagnosed heart failure” and “Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society For Preventive Cardiology Clinical Practice Statement“.

03-08-22 Congratulations Maryam Zekavat for defending her PhD and for the publication of her most recent work. “Fibrillar Collagen Variants in Spontaneous Coronary Artery Dissection“.

03-07-22 Yet more papers published “Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society for Preventive Cardiology Clinical Practice Statement.” and “Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study“.

2-28-22 The next paper out from the Natarajan Lab is “Diastolic Blood Pressure Alleles Improve Congenital Heart Defect Repair Outcomes.”

2-18-22 A slew of papers have been published over the last month in the Natarajan Lab. Here are a few of them. Michael Honigberg presented his latest research in “Microvascular Outcomes in Women With a History of Hypertension in Pregnancy“. Mark Trinder published his work titled “Repeat Measures of Lipoprotein(a) Molar Concentration and Cardiovascular Risk“. Base on her most recent studies, Leland Hull published her piece “Self-rated family health history knowledge among All of Us program participants“. Watch here for more publications!

1-13-22 More welcomes are in order as the Natarajan lab continues to grow. Welcome to Yunfeng Ruan, Buu Troung, Michael Pang, Nishant Uppal.

11-24-21 Welcome to Jacqueline Dron, Akl Fahed, and Aniruddh Patel!

11-8-21 Congratulations to the Natarajan Lab including Maryam Zekevat, Vineet Raghu, Mark Trinder, Satoshi Koyama, Mike Honigberg, Zhi Yu, Sarah Urbut, Sara Haidermota, and Pradeep Natarajan for publishing Deep Learning of the Retina Enables Phenome- and Genome-wide Analyses of the Microvasculature .

10-18-21 Despite being in her first year as a Cardiology Fellow, Dr. Sarah Urbut came in 2nd place in the Fellows Basic Science Category at the Northwestern Cardiovascular Young Investigators’ Forum. Congratulations Dr. Urbut!

9-28-21 Newsweek published their list of the world’s Best Specialized Hospitals 2022 – Cardiology. At the top, you will find the Massachusetts General Hospital Corrigan Minehan Heart Center! Congratulations to all who make this a world-class center.

 

Publications

[Updated 4/2/2024]

Pradeep Natarajan’s National Institutes of Health complete bibliography

 Select Unpublished Preprints

98. Schuermans A, Pournamdari A … Natarajan P et al. Integrative proteomic analyses across common cardiac diseases yield new mechanistic insights and enhanced prediction. medRxiv [Preprint]. 2023 Dec 19:2023.12.19.23300218. doi: 10.1101/2023.12.19.23300218. PMID: 38196601; PMCID: PMC10775327.2023.12.19.23300218.

97. Koyama S, Wang Y, Paruchuri K… Natarajan P et al. Decoding Genetics, Ancestry, and Geospatial Context for Precision Health. medRxiv [Preprint]. 2023 Oct 25:2023.10.24.23297096. doi: 10.1101/2023.10.24.23297096. PMID: 37961173; PMCID: PMC10635180.

96. Wang Y, Selvaraj MS… Natarajan P, Peloso GM et al. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study. medRxiv [Preprint]. 2023 Jun 29:2023.06.28.23291966. doi: 10.1101/2023.06.28.23291966. PMID: 37425772; PMCID: PMC10327287.

95. Yu Z, Vromman A… Natarajan P et al. Human Plasma Proteomic Profile of Clonal Hematopoiesis. bioRxiv. 2023 Jan 1;2023.07.25.550557.

94. Uddin MM, Yu Z… Natarajan P et al. Germline genomic and phenomic landscape of clonal hematopoiesis in 323,112 individuals. medRxiv. 2022 Jan 1;2022.07.29.22278015

 Select Published

93. Zou RS, Ruan Y… Fahed A*, Natarajan P* et al. Polygenic Scores and Preclinical Cardiovascular Disease in Individuals With HIV: Insights From the REPRIEVE Trial. J Am Heart Assoc. 2024 Apr 2;13(7):e033413. doi: 10.1161/JAHA.123.033413. Epub 2024 Mar 27. PMID: 38533953.

92. Yu Z, Coorens THH… Natarajan P et al. Genetic variation across and within individuals. Nat Rev Genet. 2024 Mar 28. doi: 10.1038/s41576-024-00709-x. Epub ahead of print. PMID: 38548833.

91. Small AM, Pournamdari A… Natarajan P et al. Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations. JAMA Cardiol. 2024 Feb 14. doi: 10.1001/jamacardio.2023.5605. Epub ahead of print. PMID: 38353970.

90. Cho SMJ, Lee H… Natarajan P et al. Cumulative Diastolic Blood Pressure Burden in Normal Systolic Blood Pressure and Cardiovascular Disease. Hypertension. 2023 Dec 12. doi: 10.1161/HYPERTENSIONAHA.123.22160. Epub ahead of print. PMID: 38084606.

89. Nakao T, Natarajan P. Familial Clonal Hematopoiesis in a Long Telomere Syndrome. N Engl J Med. 2023 Oct 19;389(16):1535. doi: 10.1056/NEJMc2309139. PMID: 37851887.

88. Fahed AC, Natarajan P. Clinical applications of polygenic risk score for coronary artery disease through the life course. Atherosclerosis. 2023 Oct 18;386:117356. doi: 10.1016/j.atherosclerosis.2023.117356. Epub ahead of print. PMID: 37931336.

87. Reeskamp LF, Tromp TR… Natarajan P, Khera AV et al. Concordance of a High Lipoprotein(a) Concentration Among Relatives. JAMA Cardiol. 2023 Oct 11:e233548. doi: 10.1001/jamacardio.2023.3548. Epub ahead of print. PMID: 37819667; PMCID: PMC10568442.

86. Urbut SM, Koyama S… Patel A*, Natarajan P*  et al. Bayesian multivariate genetic analysis improves translational insights. iScience. 2023 Sep 9;26(10):107854. doi: 10.1016/j.isci.2023.107854. PMID: 37766997; PMCID: PMC10520309.

85. Lee J, Jukarainen S… Natarajan P et al. Quantifying the causal impact of biological risk factors on healthcare costs. Nat Commun. 2023 Sep 13;14(1):5672. doi: 10.1038/s41467-023-41394-4. PMID: 37704630; PMCID: PMC10499912.

84. Kathiresan N, Cho SMJ… Natarajan P et al. Representation of Race and Ethnicity in the Contemporary US Health Cohort All of Us Research Program. JAMA Cardiol. 2023 Aug 16:e232411. doi: 10.1001/jamacardio.2023.2411. Epub ahead of print. PMID: 37585212; PMCID: PMC10433138.

83. Yu Z, Filder TP… Natarajan P et al. Genetic modification of inflammation and clonal hematopoiesis-associated cardiovascular risk. J Clin Invest. 2023 Jul 27:e168597. doi: 10.1172/JCI168597. Epub ahead of print. PMID: 37498674.

82. Patel AP*, Wang M*… Natarajan P*, Khera AV* et al. A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease. Nat Med. 2023 Jul 6. doi: 10.1038/s41591-023-02429-x. Epub ahead of print. PMID: 37414900.

81. Klarin D*, Devineni P*, Sendamarai AK*… Natarajan P, Tsao PS*, Pyarajan S*, Damrauer SM* et al. Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program. Nat Genet. 2023 Jun 12. doi: 10.1038/s41588-023-01420-z. Epub ahead of print. PMID: 37308786.

80. Cho SMJ, Koyama S… Natarajan P et al. Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study. Eur Heart J. 2023 Jun 23:ehad380. doi: 10.1093/eurheartj/ehad380. Epub ahead of print. PMID: 37350734.

79. Wong WJ, Emdin C… Ebert BL*, Natarajan P* et al. Clonal haematopoiesis and risk of chronic liver disease. Nature. 2023 Apr;616(7958):747-754. doi: 10.1038/s41586-023-05857-4. Epub 2023 Apr 12. PMID: 37046084.

78. Small AM*, Peloso G*… Natarajan P*, O’Donnell CJ* et al. Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program. Circulation. 2023 Feb 20. doi: 10.1161/CIRCULATIONAHA.122.061451. Epub ahead of print. PMID: 36802703.

77. Natarajan P. 2022 Jeffrey M. Hoeg Award Lecture: Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2022 Nov 10. doi: 10.1161/ATVBAHA.122.318181. Epub ahead of print. PMID: 36353993.

76. Selvaraj MS, Li X… Peloso GM*, Natarajan P* et al. Whole genome sequence analysis of blood lipid levels in >66,000 individuals. Nat Commun. 2022 Oct 11;13(1):5995. doi: 10.1038/s41467-022-33510-7. PMID: 36220816

75. Uddin MDM, Nguyen NQH… Natarajan P*, Conneely KN* et al. Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease. Nat Commun. 2022 Sep 12;13(1):5350. doi: 10.1038/s41467-022-33093-3. PMID: 36097025.

74. Tahir UA*, Katz DH*, Avila-Pachecho J*… Clish CB*, Natarajan P*, Gerszten RE* et al. Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals. Nat Commun. 2022 Aug 22;13(1):4923. doi: 10.1038/s41467-022-32275-3. PMID: 35995766.

73. Uddin MM, Zhou Y… Natarajan P*, Reiner AP*, Kitzman JO* et al. Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics. Immun Ageing. 2022 May 24;19(1):23. doi: 10.1186/s12979-022-00278-9. PMID: 35610705.

72. Klarin D, Natarajan P. Clinical utility of polygenic risk scores for coronary artery disease. Nat Rev Cardiol. 2022 May;19(5):291-301. doi: 10.1038/s41569-021-00638-w. Epub 2021 Nov 22. PMID: 34811547.

71. Yu Z, Zekavat SM… Natarajan P et al. Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways. Sci Adv. 2022 Apr 22;8(16):eabl4602. doi: 10.1126/sciadv.abl4602. Epub 2022 Apr 22. PMID: 35452290.

70. Nakao T, Bick AG… Natarajan P et al. Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential. Sci Adv. 2022 Apr 8;8(14):eabl6579. doi: 10.1126/sciadv.abl6579. Epub 2022 Apr 6. PMID: 35385311; PMCID: PMC8986098.

69. Zekavat SM*, Chou EL*… Natarajan P*, Lindsay ME* et al. Fibrillar Collagen Variants in Spontaneous Coronary Artery Dissection. JAMA Cardiol. 2022 Apr 1;7(4):396-406. doi: 10.1001/jamacardio.2022.0001. PMID: 35234813; PMCID: PMC8892371.

68. Hull LE, Natarajan P. Self-rated family health history knowledge among All of Us program participants. Genet Med. 2022 Apr;24(4):955-961. doi: 10.1016/j.gim.2021.12.006. Epub 2022 Jan 17. PMID: 35058155; PMCID: PMC8995381.

67. Bhattacharya R, Zekavat SM… Natarajan P, Reiner AP et al. Clonal Hematopoiesis Is Associated With Higher Risk of Stroke. Stroke. 2022 Mar;53(3):788-797. doi: 10.1161/STROKEAHA.121.037388. Epub 2021 Nov 8. PMID: 34743536; PMCID: PMC8885769

66. Trinder M, Paruchuri K… Natarajan P et al. Repeat Measures of Lipoprotein(a) Molar Concentration and Cardiovascular Risk. J Am Coll Cardiol. 2022 Feb 22;79(7):617-628. doi: 10.1016/j.jacc.2021.11.055. PMID: 35177190.

65. Honigberg MC, Ye Y… Natarajan P et al. Low depression frequency is associated with decreased risk of cardiometabolic disease. Nat Cardiovasc Res. 2022 Feb;1(2):125-131. doi: 10.1038/s44161-021-00011-7. Epub 2022 Feb 14. PMID: 35991864; PMCID: PMC9389944.

64. Honigberg MC, Zekavat SM, Raghu VK, Natarajan P. Microvascular Outcomes in Women With a History of Hypertension in Pregnancy. Circulation. 2022 Feb 15;145(7):552-554. doi: 10.1161/CIRCULATIONAHA.121.057139. Epub 2022 Feb 14. PMID: 35157520.

63. Yu Z, Zekavat SM, Honigberg MC, Natarajan P. Genetic IL-6 Signaling Modifies Incident Coronary Artery Disease Risk in Chronic Kidney Disease. J Am Coll Cardiol. 2022 Feb 1;79(4):415-416. doi: 10.1016/j.jacc.2021.11.020. PMID: 35086662.

62. Bick AG, Popadin K… Natarajan P, Fellay J. et al. Swiss HIV Cohort Study. Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV. Sci Rep. 2022 Jan 12;12(1):577. doi: 10.1038/s41598-021-04308-2. PMID: 35022435; PMCID: PMC8755790.

61. Zekavat SM, Raghu VK… Natarajan P et al. Deep Learning of the Retina Enables Phenome- and Genome-Wide Analyses of the Microvasculature. Circulation. 2022 Jan 11;145(2):134-150. doi: 10.1161/CIRCULATIONAHA.121.057709. Epub 2021 Nov 8. PMID: 34743558; PMCID: PMC8746912.

60. Graham SE, Clarke SL… Natarajan P…Willer CJ et al. The power of genetic diversity in genome-wide association studies of lipids. Nature. 2021 Dec;600(7890):675-679. doi: 10.1038/s41586-021-04064-3. Epub 2021 Dec 9. PMID: 34887591; PMCID: PMC8730582.

59. Niroula A, Sekar A… Natarajan P, Ebert BL et al. Distinction of lymphoid and myeloid clonal hematopoiesis. Nat Med. 2021 Nov;27(11):1921-1927. doi: 10.1038/s41591-021-01521-4. Epub 2021 Oct 18. PMID: 34663986; PMCID: PMC8621497.

58. Paruchuri K, Finneran P… Natarajan P et al. Outcomes of a smartphone-based application with live health-coaching post-percutaneous coronary intervention. EBioMedicine. 2021 Oct;72:103593. doi: 10.1016/j.ebiom.2021.103593. Epub 2021 Oct 14. PMID: 34657825; PMCID: PMC8577401.

57. Bhattacharya R, Zekavat SM… Natarajan P et al. Association of Diet Quality With Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events. JAMA Cardiol. 2021 Sep 1;6(9):1069-1077. doi: 10.1001/jamacardio.2021.1678. PMID: 34106216; PMCID: PMC8190703.

56. Brockman DG, Austin-Tse CA… Natarajan P… Udler MS et al. Randomized prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test. Genet Med. 2021 Sep;23(9):1689-1696. doi: 10.1038/s41436-021-01193-y. Epub 2021 May 11. PMID: 33976420; PMCID: PMC8488861.

55. Honigberg MC, Zekavat SM, Pirruccello JP, Natarajan P, Vaduganathan M. Cardiovascular and Kidney Outcomes across the Glycemic Spectrum: Insights from the UK Biobank. J Am Coll Cardiol. 2021 Aug 3;78(5):453-464. doi: 10.1016/j.jacc.2021.05.004. Epub 2021 May 17. PMID: 34015477; PMCID: PMC8324525.

54. Natarajan P, McNally EM. Knowing More Than the Knowns in Familial Hypercholesterolemia. JAMA Cardiol. 2021 Aug 1;6(8):909. doi: 10.1001/jamacardio.2021.1458. PMID: 34037679.

53. Miksenas H, Januzzi JL Jr, Natarajan P. Lipoprotein(a) and Cardiovascular Diseases. JAMA. 2021 Jul 27;326(4):352-353. doi: 10.1001/jama.2021.3632. PMID: 34236417.

52. Yu B, Roberts MB… Natarajan P, Eaton CB; National Heart, Lung, and Blood Institute TOPMed Consortium et al. Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure. J Am Coll Cardiol. 2021 Jul 6;78(1):42-52. doi: 10.1016/j.jacc.2021.04.085. PMID: 34210413; PMCID: PMC8313294.

51. Zekavat SM, Lin SH… Natarajan P et al. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Nat Med. 2021 Jun;27(6):1012-1024. doi: 10.1038/s41591-021-01371-0. Epub 2021 Jun 7. PMID: 34099924; PMCID: PMC8245201.

50. Natarajan P, Pampana A… Peloso GM et al. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. Nat Commun. 2021 Apr 12;12(1):2182. doi: 10.1038/s41467-021-22339-1. PMID: 33846329; PMCID: PMC8042019.

49. Honigberg MC, Zekavat SM… Natarajan P et al. Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women. Circulation. 2021 Feb 2;143(5):410-423. doi: 10.1161/CIRCULATIONAHA.120.051775. Epub 2020 Nov 9. PMID: 33161765; PMCID: PMC7911856.

48. Taliun D*, Harris DN*, Kessler MD*, Carlson J*, Szpiech ZA*, Torres R*, Taliun SAG*, Corvelo A*… Natarajan P… Abecasis GR et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021 Feb;590(7845):290-299. doi: 10.1038/s41586-021-03205-y. Epub 2021 Feb 10. PMID: 33568819; PMCID: PMC7875770.

47. Nielsen JB*, Rom O*, Surakka I*, Graham SE*, Zhou W*… Natarajan P…Chen YE*, Willer CJ*, Hveem K* et al. Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease. Nat Commun. 2020 Dec 18;11(1):6417. doi: 10.1038/s41467-020-20086-3. PMID: 33339817; PMCID: PMC7749177.

46. Natarajan A, Pantelopoulos A, Emir-Farinas H, Natarajan P. Heart rate variability with photoplethysmography in 8 million individuals: a cross-sectional study. Lancet Digit Health. 2020 Dec;2(12):e650-e657. doi: 10.1016/S2589-7500(20)30246-6. Epub 2020 Nov 23. PMID: 33328029.

45. Klarin D, Verma SS… Natarajan P… Damrauer SM*, Tsao PS* et al; Veterans Affairs Million Veteran Program. Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program. Circulation. 2020 Oct 27;142(17):1633-1646. doi: 10.1161/CIRCULATIONAHA.120.047544. Epub 2020 Sep 28. PMID: 32981348; PMCID: PMC7580856.

44. Trinder M, Uddin MM, Finneran P, Aragam KG, Natarajan P. Clinical Utility of Lipoprotein(a) and LPA Genetic Risk Score in Risk Prediction of Incident Atherosclerotic Cardiovascular Disease. JAMA Cardiol. 2020 Oct 6:e205398. doi: 10.1001/jamacardio.2020.5398. Epub ahead of print. PMID: 33021622; PMCID: PMC7539232.

43. Bick AG*, Weinstock JS*… Kathiresan S*, Natarajan P* et al. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020 Oct;586(7831):763-768. doi: 10.1038/s41586-020-2819-2. Epub 2020 Oct 14. Erratum in: Nature. 2021 Mar;591(7851):E27. PMID: 33057201; PMCID: PMC7944936.

42. Bao EL*, Nandakumar SK*, Liao X*… Natarajan P… Sankaran VG et al. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature. 2020 Oct;586(7831):769-775. doi: 10.1038/s41586-020-2786-7. Epub 2020 Oct 14. PMID: 33057200; PMCID: PMC7606745.

41. Ferraro NM, Strober BJ… Natarajan P; GTEx Consortium, Lappalainen T, Mohammadi P, Montgomery SB, Battle A et al. Transcriptomic signatures across human tissues identify functional rare genetic variation. Science. 2020 Sep 11;369(6509):eaaz5900. doi: 10.1126/science.aaz5900. Epub 2020 Sep 10. PMID: 32913073; PMCID: PMC7646251.

40. Li X*, Li Z*… Natarajan P, Lin X et al. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet. 2020 Sep;52(9):969-983. doi: 10.1038/s41588-020-0676-4. Epub 2020 Aug 24. PMID: 32839606; PMCID: PMC7483769.

39. Honigberg MC, Chaffin M… Natarajan P et al. Genetic Variation in Cardiometabolic Traits and Medication Targets and the Risk of Hypertensive Disorders of Pregnancy. Circulation. 2020 Aug 18;142(7):711-713. doi: 10.1161/CIRCULATIONAHA.120.047936. Epub 2020 Aug 17. PMID: 32804569; PMCID: PMC7436942.

38. Aragam KG*, Dobbyn A*… Do R*, Damrauer SM*, Natarajan P* et al. Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease. J Am Coll Cardiol. 2020 Jun 9;75(22):2769-2780. doi: 10.1016/j.jacc.2020.04.027. PMID: 32498804; PMCID: PMC7346975.

37. Aragam KG, Natarajan P. Polygenic Scores to Assess Atherosclerotic Cardiovascular Disease Risk: Clinical Perspectives and Basic Implications. Circ Res. 2020 Apr 24;126(9):1159-1177. doi: 10.1161/CIRCRESAHA.120.315928. Epub 2020 Apr 23. PMID: 32324503. PMCID: PMC7926201.

36. Bick AG*, Pirruccello JP*… Natarajan P et al. Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis. Circulation. 2020 Jan 14;141(2):124-131. doi: 10.1161/CIRCULATIONAHA.119.044362. Epub 2019 Nov 11. PMID: 31707836; PMCID: PMC7008855.

35. Honigberg MC, Zekavat SM… Natarajan P et al. Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy. J Am Coll Cardiol. 2019 Dec 3;74(22):2743-2754. doi: 10.1016/j.jacc.2019.09.052. Epub 2019 Nov 11. PubMed PMID: 31727424; PubMed Central PMCID: PMC6981240.

34. Honigberg MC, Zekavat SM… Natarajan P et al. Association of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease. JAMA. 2019 Dec 24;322(24):2411-2421. doi: 10.1001/jama.2019.19191. PMID: 31738818; PMCID: PMC7231649.

33. Honigberg MC, Natarajan P. Bempedoic Acid for Lowering LDL Cholesterol. JAMA. 2019 Nov 12;322(18):1769-1771. doi: 10.1001/jama.2019.16598. PMID: 31714973; PMCID: PMC6865332.

32. Klarin D, Busenkell E… Damrauer SM*, Natarajan P*, INVENT Consortium, VA Million Veteran Program et al. Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease. Nat Genet. 2019 Nov;51(11):1574-1579. doi: 10.1038/s41588-019-0519-3. Epub 2019 Nov 1. PMID: 31676865; PMCID: PMC6858581.

31. Bick AG*, Akwo E*, Robinson-Cohen C*… Natarajan P… Damrauer SM; VA Million Veteran Program et al. Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program. Circulation. 2019 Sep 17;140(12):1031-1040. doi: 10.1161/CIRCULATIONAHA.118.036589. Epub 2019 Jul 24. PMID: 31337231; PMCID: PMC6754626.

30. Klarin D, Lynch J… Natarajan P… Tsao PS*, Damrauer SM* et al. Genome-wide association study of peripheral artery disease in the Million Veteran Program. Nat Med. 2019 Aug;25(8):1274-1279. doi: 10.1038/s41591-019-0492-5. Epub 2019 Jul 8. PubMed PMID: 31285632; PubMed Central PMCID: PMC6768096.

29. Zekavat SM, Aragam K… Natarajan P et al. Genetic Association of Finger Photoplethysmography-Derived Arterial Stiffness Index With Blood Pressure and Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1253-1261. doi: 10.1161/ATVBAHA.119.312626. PubMed PMID: 31070453; PubMed Central PMCID: PMC6531323.

28. Natarajan P, Collier TS… Januzzi JL Jr et al. Association of an HDL Apolipoproteomic Score With Coronary Atherosclerosis and Cardiovascular Death. J Am Coll Cardiol. 2019 May 7;73(17):2135-2145. doi: 10.1016/j.jacc.2019.01.073. PubMed PMID: 31047001; PubMed Central PMCID: PMC6501819.

27. Klarin D*, Damrauer SM*… Natarajan P… O’Donnell CJ*, Tsao PS*, Kathiresan S*, Rader DJ*, Wilson PWF*, Assimes TL* et al. Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. Nat Genet. 2018 Nov;50(11):1514-1523. doi: 10.1038/s41588-018-0222-9. Epub 2018 Oct 1. PMID: 30275531; PMCID: PMC6521726.

26. Natarajan P. Polygenic Risk Scoring for Coronary Heart Disease: The First Risk Factor. J Am Coll Cardiol. 2018 Oct 16;72(16):1894-1897. doi: 10.1016/j.jacc.2018.08.1041. PubMed PMID: 30309465; PubMed Central PMCID: PMC6215449.

25. Khera AV*, Chaffin M*… Natarajan P… Kathiresan S et al. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z. Epub 2018 Aug 13. PubMed PMID: 30104762; PubMed Central PMCID: PMC6128408.

24. Natarajan P*, Peloso GM*, Zekavat SM*… Willer CJ*, Kathiresan S*; NHLBI TOPMed Lipids Working Group et al. Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nat Commun. 2018 Aug 23;9(1):3391. doi: 10.1038/s41467-018-05747-8. PubMed PMID: 30140000; PubMed Central PMCID: PMC6107638.

23. Zekavat SM, Ruotsalainen S… Esko T*, Ganna A*, Ripatti S*, Kathiresan S*, Natarajan P*; NHLBI TOPMed Lipids Working Group et al. Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018 Jul 4;9(1):2606. doi: 10.1038/s41467-018-04668-w. PubMed PMID: 29973585; PubMed Central PMCID: PMC6031652.

22. Natarajan P, Jaiswal S, Kathiresan S. Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis. Circ Genom Precis Med. 2018 Jul;11(7):e001926. doi: 10.1161/CIRCGEN.118.001926. Review. PubMed PMID: 29987111; PubMed Central PMCID: PMC6082163.

21. Emdin CA*, Khera AV*… Natarajan P… Kathiresan S et al. Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease. Nat Commun. 2018 Apr 24;9(1):1613. doi: 10.1038/s41467-018-03911-8. PubMed PMID: 29691411; PubMed Central PMCID: PMC5915445.

20. Emdin CA, Khera AV, Klarin D, Natarajan P… Kathiresan S et al. Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling. Circulation. 2018 Jan 16;137(3):222-232. doi: 10.1161/CIRCULATIONAHA.117.028021. Epub 2017 Oct 5. PubMed PMID: 28982690; PubMed Central PMCID: PMC5771958.

19. Klarin D*, Zhu QM*… Natarajan P; CARDIoGRAMplusC4D Consortium, Kathiresan S et al. Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease. Nat Genet. 2017 Sep;49(9):1392-1397. doi: 10.1038/ng.3914. Epub 2017 Jul 17. PubMed PMID: 28714974; PubMed Central PMCID: PMC5577383.

18. Jaiswal S, Natarajan P…Kathiresan S*, Ebert BL* et al. Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. N Engl J Med. 2017 Jul 13;377(2):111-121. doi: 10.1056/NEJMoa1701719. Epub 2017 Jun 21. PMID: 28636844; PMCID: PMC6717509.

17. Natarajan P*, Young R*… Ford I*, Sattar N*, Kathiresan S* et al. Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting. Circulation. 2017 May 30;135(22):2091-2101. doi: 10.1161/CIRCULATIONAHA.116.024436. Epub 2017 Feb 21. PubMed PMID: 28223407; PubMed Central PMCID: PMC5484076.

16. Saleheen D*, Natarajan P*… Frossard P*, Danesh J*, Rader DJ*, Kathiresan S* et al. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 2017 Apr 12;544(7649):235-239. doi: 10.1038/nature22034. PubMed PMID: 28406212; PubMed Central PMCID: PMC5600291.

15. Klarin D, Emdin CA, Natarajan P, Conrad MF; INVENT Consortium, Kathiresan S. Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. Circ Cardiovasc Genet. 2017 Apr;10(2). pii: e001643. doi: 10.1161/CIRCGENETICS.116.001643. PubMed PMID: 28373160; PubMed Central PMCID: PMC5395047.

14. Emdin CA*, Khera AV*, Natarajan P…Kathiresan S et al. Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort. Am J Cardiol. 2017 Mar 15;119(6):881-885. doi: 10.1016/j.amjcard.2016.11.042. Epub 2016 Dec 18. PubMed PMID: 28061997.

13. Khera AV*, Won HH*… Natarajan P… Kathiresan S; Myocardial Infarction Genetics Consortium, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium et al. Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. JAMA. 2017 Mar 7;317(9):937-946. doi: 10.1001/jama.2017.0972. PubMed PMID: 28267856; PubMed Central PMCID: PMC5664181.

12. Emdin CA*, Khera AV*, Natarajan P… Kathiresan S et al. Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease. JAMA. 2017 Feb 14;317(6):626-634. doi: 10.1001/jama.2016.21042. PubMed PMID: 28196256; PubMed Central PMCID: PMC5571980.

11. Khera AV*, Emdin CA*… Natarajan P… Kathiresan S et al. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N Engl J Med. 2016 Dec 15;375(24):2349-2358. doi: 10.1056/NEJMoa1605086. Epub 2016 Nov 13. PubMed PMID: 27959714; PubMed Central PMCID: PMC5338864.

10. Natarajan P*, Bis JC*… O’Donnell CJ; CHARGE Consortium et al. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016 Dec;9(6):511-520. doi: 10.1161/CIRCGENETICS.116.001572. Epub 2016 Nov 21. PubMed PMID: 27872105; PubMed Central PMCID: PMC5418659.

9. Natarajan P*, Gold NB*, Bick AG*… Kathiresan S*, Green RC* et al. Aggregate penetrance of genomic variants for actionable disorders in European and African Americans. Sci Transl Med. 2016 Nov 9;8(364):364ra151. doi: 10.1126/scitranslmed.aag2367. PMID: 27831900; PMCID: PMC5823271.

8. Lek M, Karczewski KJ*, Minikel EV*, Samocha KE*… Natarajan P… MacArthur DG; Exome Aggregation Consortium et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 2016 Aug 18;536(7616):285-91. doi: 10.1038/nature19057. PubMed PMID: 27535533; PubMed Central PMCID: PMC5018207.

7. Khera AV*, Won HH*, Peloso GM*… Natarajan P… Kathiresan S et al. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol. 2016 Jun 7;67(22):2578-89. doi: 10.1016/j.jacc.2016.03.520. Epub 2016 Apr 3. PubMed PMID: 27050191; PubMed Central PMCID: PMC5405769.

6. Natarajan P, Kathiresan S. PCSK9 Inhibitors. Cell. 2016 May 19;165(5):1037. doi: 10.1016/j.cell.2016.05.016. PubMed PMID: 27203103.

5. Natarajan P, Kohli P… Kathiresan S et al. Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study. J Am Coll Cardiol. 2015 Nov 3;66(18):2053-2055. doi: 10.1016/j.jacc.2015.08.866. PubMed PMID: 26516010; PubMed Central PMCID: PMC4706229.

4. Myocardial Infarction Genetics Consortium Investigators, Stitziel NO*, Won HH*… Natarajan P… Kathiresan S et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med. 2014 Nov 27;371(22):2072-82. doi: 10.1056/NEJMoa1405386. Epub 2014 Nov 12. PubMed PMID: 25390462; PubMed Central PMCID: PMC4335708.

3. Tatematsu S, Francis SA, Natarajan P… Plutzky J et al. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1788-94. doi: 10.1161/ATVBAHA.113.301300. Epub 2013 May 30. PubMed PMID: 23723371; PubMed Central PMCID: PMC3794714.

2. Natarajan P, Forte TM… Bielicki JK et al. Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1. J Biol Chem. 2004 Jun 4;279(23):24044-52. Epub 2004 Mar 29. doi: 10.1074/jbc.M400561200. PubMed PMID: 15051721.

1. Jia Z, Natarajan P, Forte TM, Bielicki JK. Thiol-bearing synthetic peptides retain the antioxidant activity of apolipoproteinA-I(Milano). Biochem Biophys Res Commun. 2002 Sep 20;297(2):206-13. doi: 10.1016/S0006-291X(02)02143-5. PubMed PMID: 12237103.

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